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Polar-copolymerized approach based on horizontal polymerization on silica surface for preparation of polar-modified stationary phases
Guo, Zhimou1; Wang, Chaoran1; Liang, Tu2; Liang, Xinmiao1,2
KeywordReversed-phase Liquid Chromatography Polar-modified Stationary Phases Polar-copolymerized Horizontal Polymerization
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2010-07-02
DOI10.1016/j.chroma.2010.04.068
Volume1217Issue:27Pages:4555-4560
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; MIXED TRIFUNCTIONAL SILANES ; EMBEDDED UREA GROUPS ; W. T. WANG ; HPLC ; RETENTION ; ALKYL ; STABILITY ; ALKALOIDS ; COLUMN
AbstractA new approach for preparation of polar-modified reversed-phase liquid chromatography stationary phases was developed by using horizontal polymerization technique on silica surface, which was defined as "polar-copolymerized" approach. Based on this new approach, a representative polar-copolymerized stationary phase composed of mixed n-octadecyl and chloropropyl (C18-C3C1) was synthesized. The resulting stationary phase named C18HCE was characterized with elemental analysis and solid phase (13)C and (29)Si NMR, which proved the chemistry of polar-copolymerized stationary phases. Chromatographic evaluation and application of the C18HCE were also investigated. The results of preliminary chromatographic evaluation demonstrated that the C18HCE stationary phase exhibited 100% aqueous mobile phase compatibility, low silanol activity. In addition, the application results demonstrated that the C18HCE had superior separation performance in alkaloids separation at acidic conditions compared to some commercial stationary phases. (C) 2010 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000279138600007
Citation statistics
Cited Times:48[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141682
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
Recommended Citation
GB/T 7714
Guo, Zhimou,Wang, Chaoran,Liang, Tu,et al. Polar-copolymerized approach based on horizontal polymerization on silica surface for preparation of polar-modified stationary phases[J]. JOURNAL OF CHROMATOGRAPHY A,2010,1217(27):4555-4560.
APA Guo, Zhimou,Wang, Chaoran,Liang, Tu,&Liang, Xinmiao.(2010).Polar-copolymerized approach based on horizontal polymerization on silica surface for preparation of polar-modified stationary phases.JOURNAL OF CHROMATOGRAPHY A,1217(27),4555-4560.
MLA Guo, Zhimou,et al."Polar-copolymerized approach based on horizontal polymerization on silica surface for preparation of polar-modified stationary phases".JOURNAL OF CHROMATOGRAPHY A 1217.27(2010):4555-4560.
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