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题名: Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics
作者: Gu, Yan1, 2;  Zhang, Yifei3;  Shi, Xianzhe1;  Li, Xiaoying3;  Hong, Jie3;  Chen, Jing1;  Gu, Weigiong3;  Lu, Xin1;  Xu, Guowang1;  Ning, Guang3
关键词: UPLC/MS ;  Type 2 diabetes ;  Metabonomics ;  Berberine ;  Fatty acids ;  Dyslipidemia
刊名: TALANTA
发表日期: 2010-05-15
DOI: 10.1016/j.talanta.2010.01.015
卷: 81, 期:3, 页:766-772
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: A comprehensive metabonomic method, in combination with fingerprint analysis and target analysis, was performed to reveal potential mechanisms of berberine action in the treatment of patients with type 2 diabetes and dyslipidemia. Serum samples of 60 patients before and after treatment with either berberine or placebo were collected. Ultra-performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (UPLC Q-TOF MS) coupled with pattern recognition analysis were used to identify changes in global serum metabolites. Compared with placebo, patients before and after berberine treatment could be separated into distinct clusters as displayed by the orthogonal signal correction filtered partial least-squares discriminant analysis (OSC-PLS-DA) score plot, which indicated changes in circulating metabolites after berberine treatment. Among them, free fatty acids changed markedly. These were further quantified by UPLC combined with single quadrupole mass spectrometry (UPLC SQ MS). There was a highly significant decrease in the concentrations of 13 fatty acids following berberine administration. 10 fatty acids also differed statistically from placebo. These results suggest that berberine might play a pivotal role in the treatment of type 2 diabetes through down-regulating the high level of free fatty acids and that comprehensive metabonomic measurements are potentially very useful for studying the mechanisms of action of traditional Chinese medicines. (C) 2010 Elsevier B.V. All rights reserved.
关键词[WOS]: FREE FATTY-ACIDS ;  INSULIN-RESISTANCE ;  GLUCOSE-METABOLISM ;  MASS-SPECTROMETRY ;  MELLITUS PATIENTS ;  PROTEIN-KINASE ;  SECRETION ;  LIPOTOXICITY ;  PATHOGENESIS ;  OBESITY
语种: 英语
WOS记录号: WOS:000276877500004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141705
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, Shenyang 110016, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med,Shanghai Clin Ctr Endocrine & Metab Dis, Rui Jin Hosp, Shanghai Univ,Div Endocrine & Metab Dis E Inst, Shanghai 200025, Peoples R China

Recommended Citation:
Gu, Yan,Zhang, Yifei,Shi, Xianzhe,et al. Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics[J]. TALANTA,2010,81(3):766-772.
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