中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Lysophosphatidylcholine profiling of plasma: discrimination of isomers and discovery of lung cancer biomarkers
作者: Dong, Jun1, 2;  Cai, Xiaoming2;  Zhao, Lili1;  Xue, Xingya2;  Zou, Lijuan1;  Zhang, Xiuli2;  Liang, Xinmiao2
关键词: Lysophosphatidylcholine ;  Isomers ;  Discrimination ;  Metabonomics ;  Lung cancer
刊名: METABOLOMICS
发表日期: 2010-12-01
DOI: 10.1007/s11306-010-0215-x
卷: 6, 期:4, 页:478-488
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
英文摘要: Lysophosphatidylcholines (lysoPCs) are a class of compounds that have a constant polar head, and fatty acyls of different chain lengths, position, degrees of saturation, and double bond location in human plasma. LysoPCs levels can be a clinical diagnostic indicator that reveals pathophysiological changes. In this work, a method was developed to discriminate between different types of lysoPCs using reversed phase ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry, using mass spectrometry MS(E). Isomeric lysoPCs were distinguished based on retention time and the peak intensity ratio of product ions, and 14 pairs of lysoPCs regioisomers were identified in human plasma. The plasma samples of 12 lung cancer patients and 12 healthy persons were collected and analyzed by principal component analysis to generate metabolic profiles of the identified lysoPCs. Both electrospray ionization ESI+ and ESI- results showed that all lung cancer patients had the same five lysoPC metabolic abnormalities, specifically in sn-1 lyso16:0, sn-2 lysoPC 16:0, sn-1 lysoPC 18:0, sn-1 lysoPC 18:1 and sn-1 lysoPC 18:2. Thus, the function of isomers with different fatty acyl positions may be related to lung cancer, and this may help elucidate the mechanism of the disease.
关键词[WOS]: UPLC-OATOF-MS ;  CHROMATOGRAPHY-MASS SPECTROMETRY ;  DIABETES-MELLITUS ;  METABONOMICS RESEARCH ;  POTENTIAL BIOMARKERS ;  METABOLISM ;  RAT ;  LYSOPHOSPHOLIPIDS ;  PHOSPHATIDYLCHOLINE ;  CELLS
语种: 英语
WOS记录号: WOS:000283944300002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141708
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Dalian Med Univ, Dalian 116044, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Dong, Jun,Cai, Xiaoming,Zhao, Lili,et al. Lysophosphatidylcholine profiling of plasma: discrimination of isomers and discovery of lung cancer biomarkers[J]. METABOLOMICS,2010,6(4):478-488.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Dong, Jun]'s Articles
 [Cai, Xiaoming]'s Articles
 [Zhao, Lili]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Dong, Jun]‘s Articles
 [Cai, Xiaoming]‘s Articles
 [Zhao, Lili]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace