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题名: Electrospray ionization mass spectrometry probing of formation and recognition of the G-quadruplex in the proximal promoter of the human vascular endothelial growth factor gene
作者: Li, Huihui1, 2;  Yuan, Gu1
刊名: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
发表日期: 2010-07-01
DOI: 10.1002/rcm.4613
卷: 24, 期:14, 页:2030-2034
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences ;  Technology
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical ;  Spectroscopy
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Spectroscopy
英文摘要: The formation of the G-quadruplex of the vascular endothelial growth factor (VEGF) gene was probed by electrospray ionization mass spectrometry (ESI-MS). It found that cations (K(+) and NH(4)(+)), CH(3)OH and pH influence significantly the formation of the G-quadruplex structure. Additionally, a perylene derivative (P3) and polydatin (P4) have shown to be potential G-quadruplex binding agents with structurally specific recognition. Copyright (C) 2010 John Wiley & Sons, Ltd.
关键词[WOS]: I-MOTIF STRUCTURES ;  C-MYC PROMOTER ;  TUMOR ANGIOGENESIS ;  INTERACTIVE AGENTS ;  FACTOR EXPRESSION ;  FORMING REGION ;  SMALL-MOLECULE ;  CANCER CELLS ;  DNA ;  TRANSCRIPTION
语种: 英语
WOS记录号: WOS:000280117200013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141740
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Nanjing Normal Univ, Jiangsu Key Lab Biofunct Mat, Sch Chem & Environm Sci, Nanjing 210097, Peoples R China

Recommended Citation:
Li, Huihui,Yuan, Gu. Electrospray ionization mass spectrometry probing of formation and recognition of the G-quadruplex in the proximal promoter of the human vascular endothelial growth factor gene[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2010,24(14):2030-2034.
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