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题名: pH-Sensitive mesoporous zirconium diphosphonates for controllable colon-targeted delivery
作者: Shi, Xin1;  Li, JianPing1;  Tang, Yan1;  Yang, Qihua2
刊名: JOURNAL OF MATERIALS CHEMISTRY
发表日期: 2010
DOI: 10.1039/c0jm00587h
卷: 20, 期:31, 页:6495-6504
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Physical ;  Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ;  Materials Science
英文摘要: pH-Sensitive mesoporous zirconium diphosphonates have been successfully synthesized through the surfactant-assisted procedure using the organophosphonate derivative of piperazine, 1,4-bis(phosphomethyl)piperazine (BPMP), and ZrCl4 as the metal precursor. The pH-sensitivity was derived from the reversible protonation-deprotonation of piperazine groups integrated in the mesoporous walls under different pH values, which endows mesoporous zirconium diphosphonates with reversible cationic-neutral surface properties. These pH-sensitive materials can effectively adsorb PDS (dinuclear cobalt phthalocyanine ammonium sulfonate, a photosensitizer of sulfonated phthalocyanine for photodynamic therapy of tumors) through strong electrostatic interaction. The PDS-loaded samples exhibit pH-dependent release behaviors for PDS in physiological buffer solutions as evidenced by the fact that almost no PDS release can be observed in simulated gastric fluid (pH 1.2) and a sustained release of PDS with a slower initial release rate was triggered with the electrostatic interaction disappearing due to the deprotonation of piperazine groups in the mesoporous walls under the weakly basic medium of simulated intestinal fluid (pH 7.5). The pH-sensitive mesoporous zirconium diphosphonates as smart carriers for pH-controllable release of anionic photosensitizer can be used to develop an oral colon-targeted drug delivery system in which the drug molecules will be trapped without release when passing through the stomach, and be released completely in a sustained-release method in the colon followed by a minimal drug release in the small intestine.
关键词[WOS]: CONTROLLED DRUG-DELIVERY ;  CORE-SHELL STRUCTURE ;  ALUMINUM ORGANOPHOSPHONATES ;  ANTIINFLAMMATORY DRUG ;  RELEASE ;  SILICA ;  ADSORPTION ;  SYSTEM ;  ACID ;  PORE
语种: 英语
WOS记录号: WOS:000280398300018
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141771
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Liaoning Normal Univ, Inst Chem Functionalized Mat, Dept Chem & Chem Engn, Dalian 116029, Peoples R China
2.Chinese Acad Sci, State Key Lab Catalysis, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Shi, Xin,Li, JianPing,Tang, Yan,et al. pH-Sensitive mesoporous zirconium diphosphonates for controllable colon-targeted delivery[J]. JOURNAL OF MATERIALS CHEMISTRY,2010,20(31):6495-6504.
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