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题名: Purification of polar compounds from Radix isatidis using conventional C18 column coupled with polar-copolymerized C18 column
作者: Zeng, Jing1;  Guo, Zhimou1;  Xiao, Yuansheng1;  Wang, Chaoran1;  Zhang, Xiuli1;  Liang, Xinmiao1
关键词: Banlangen ;  Polar compounds ;  Polar-copolymerized C18 ;  Radix isatidis ;  RP/RP-LC
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2010-11-01
DOI: 10.1002/jssc.201000417
卷: 33, 期:21, 页:3341-3346
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Regarding hydrophilic interaction chromatography and normal phase liquid chromatography, RPLC is another choice used to separate polar compounds with the improvement of polar-modified C18 stationary phase. In this study, a method using conventional C18 column coupled with polar-copolymerized C18 column was successfully developed for the separation and purification of polar compounds from Radix isatidis, which is one of the most commonly used traditional Chinese medicines (TCMs). An XTerra MS C18 column was used to fractionate the extract of R. isatidis and a homemade polar-copolymerized C18 column was utilized for the final purification due to its good separation selectivity and high resolution for polar compounds. The established purification system demonstrated good orthogonality for the polar compounds. As a result, ten compounds were purified and three of them were identified as 3-methyl-5-vinyloxazolidin-2-one (compound A), 5-hydroxymethyl-2-furaldehyde (compound B) and 3-methylfuran-2-carboxylic acid (compound G) based on the MS, IR and extensive NMR data, respectively. It was demonstrated to be a feasible and powerful technique for the purification of polar compounds under RPLC mode and more chemical information of TCMs will be obtained to interpret the efficiency of TCMs.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  STATIONARY PHASES ;  CIGARETTE-SMOKE ;  SEPARATION ;  FURANS
语种: 英语
WOS记录号: WOS:000284230700010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141772
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Key Lab Nat Med, Dalian 116023, Peoples R China

Recommended Citation:
Zeng, Jing,Guo, Zhimou,Xiao, Yuansheng,et al. Purification of polar compounds from Radix isatidis using conventional C18 column coupled with polar-copolymerized C18 column[J]. JOURNAL OF SEPARATION SCIENCE,2010,33(21):3341-3346.
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