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题名: Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion
作者: Yang, Yan2, 3;  Liu, Xiudong1;  Yu, Weiting2;  Zhou, Houjiang2, 3;  Li, Xiaoxia2, 3;  Ma, Xiaojun2
关键词: Homogeneous synthesis ;  Chitosan ;  Hydroxyl ;  Photochemistry ;  Cell adhesion
刊名: CARBOHYDRATE POLYMERS
发表日期: 2010-05-05
DOI: 10.1016/j.carbpol.2009.12.019
卷: 80, 期:3, 页:733-739
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: A novel homogeneous synthesis route was presented to produce RGD-containing peptide modified chitosan (CTS) with purpose of improving cell adhesion and growth. Bifunctional photosensitive crosslinker, Sulfo-SANPAH, was used to link cell adhesive peptide GRGDY and CTS under controlled condition. The synthesis process was proved by FTIR, MALDI-TOF MS and (1)H NMR analyses, and the mechanism was demonstrated clearly and completely that hydroxyl groups of CTS were prior: to amino groups for nucleophilic reaction with Sulfo-SANPAH. Moreover, cell adhesion and proliferation were evaluated for GRGDY grafted CTS. The results showed that GRGDY grafted CTS formed by the novel strategy had potential application not only as drug or gene carriers but also as tissue engineered scaffolds. (C) 2009 Elsevier Ltd. All rights reserved.
关键词[WOS]: ARG-GLY-ASP ;  HUMAN ENDOTHELIAL-CELLS ;  IN-VIVO ;  CHITOSAN-GRAFT-POLY(ETHYLENE GLYCOL) ;  DRUG-DELIVERY ;  RGD PEPTIDE ;  GROWTH ;  SURFACE ;  PROLIFERATION ;  NANOPARTICLE
语种: 英语
WOS记录号: WOS:000276987800015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141786
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Yang, Yan,Liu, Xiudong,Yu, Weiting,et al. Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion[J]. CARBOHYDRATE POLYMERS,2010,80(3):733-739.
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