DICP OpenIR
Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion
Yang, Yan2,3; Liu, Xiudong1; Yu, Weiting2; Zhou, Houjiang2,3; Li, Xiaoxia2,3; Ma, Xiaojun2
KeywordHomogeneous Synthesis Chitosan Hydroxyl Photochemistry Cell Adhesion
Source PublicationCARBOHYDRATE POLYMERS
2010-05-05
DOI10.1016/j.carbpol.2009.12.019
Volume80Issue:3Pages:733-739
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS Research AreaChemistry ; Polymer Science
WOS KeywordARG-GLY-ASP ; HUMAN ENDOTHELIAL-CELLS ; IN-VIVO ; CHITOSAN-GRAFT-POLY(ETHYLENE GLYCOL) ; DRUG-DELIVERY ; RGD PEPTIDE ; GROWTH ; SURFACE ; PROLIFERATION ; NANOPARTICLE
AbstractA novel homogeneous synthesis route was presented to produce RGD-containing peptide modified chitosan (CTS) with purpose of improving cell adhesion and growth. Bifunctional photosensitive crosslinker, Sulfo-SANPAH, was used to link cell adhesive peptide GRGDY and CTS under controlled condition. The synthesis process was proved by FTIR, MALDI-TOF MS and (1)H NMR analyses, and the mechanism was demonstrated clearly and completely that hydroxyl groups of CTS were prior: to amino groups for nucleophilic reaction with Sulfo-SANPAH. Moreover, cell adhesion and proliferation were evaluated for GRGDY grafted CTS. The results showed that GRGDY grafted CTS formed by the novel strategy had potential application not only as drug or gene carriers but also as tissue engineered scaffolds. (C) 2009 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000276987800015
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141786
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yan,Liu, Xiudong,Yu, Weiting,et al. Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion[J]. CARBOHYDRATE POLYMERS,2010,80(3):733-739.
APA Yang, Yan,Liu, Xiudong,Yu, Weiting,Zhou, Houjiang,Li, Xiaoxia,&Ma, Xiaojun.(2010).Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion.CARBOHYDRATE POLYMERS,80(3),733-739.
MLA Yang, Yan,et al."Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion".CARBOHYDRATE POLYMERS 80.3(2010):733-739.
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