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Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion
Yang, Yan2,3; Liu, Xiudong1; Yu, Weiting2; Zhou, Houjiang2,3; Li, Xiaoxia2,3; Ma, Xiaojun2
关键词Homogeneous Synthesis Chitosan Hydroxyl Photochemistry Cell Adhesion
刊名CARBOHYDRATE POLYMERS
2010-05-05
DOI10.1016/j.carbpol.2009.12.019
80期:3页:733-739
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]ARG-GLY-ASP ; HUMAN ENDOTHELIAL-CELLS ; IN-VIVO ; CHITOSAN-GRAFT-POLY(ETHYLENE GLYCOL) ; DRUG-DELIVERY ; RGD PEPTIDE ; GROWTH ; SURFACE ; PROLIFERATION ; NANOPARTICLE
英文摘要A novel homogeneous synthesis route was presented to produce RGD-containing peptide modified chitosan (CTS) with purpose of improving cell adhesion and growth. Bifunctional photosensitive crosslinker, Sulfo-SANPAH, was used to link cell adhesive peptide GRGDY and CTS under controlled condition. The synthesis process was proved by FTIR, MALDI-TOF MS and (1)H NMR analyses, and the mechanism was demonstrated clearly and completely that hydroxyl groups of CTS were prior: to amino groups for nucleophilic reaction with Sulfo-SANPAH. Moreover, cell adhesion and proliferation were evaluated for GRGDY grafted CTS. The results showed that GRGDY grafted CTS formed by the novel strategy had potential application not only as drug or gene carriers but also as tissue engineered scaffolds. (C) 2009 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000276987800015
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141786
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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GB/T 7714
Yang, Yan,Liu, Xiudong,Yu, Weiting,et al. Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion[J]. CARBOHYDRATE POLYMERS,2010,80(3):733-739.
APA Yang, Yan,Liu, Xiudong,Yu, Weiting,Zhou, Houjiang,Li, Xiaoxia,&Ma, Xiaojun.(2010).Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion.CARBOHYDRATE POLYMERS,80(3),733-739.
MLA Yang, Yan,et al."Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion".CARBOHYDRATE POLYMERS 80.3(2010):733-739.
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