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题名: Treatment of Acute Hepatic Failure in Mice by Transplantation of Mixed Microencapsulation of Rat Hepatocytes and Transgenic Human Fetal Liver Stromal Cells
作者: Teng, Yue2;  Wang, Yunfang2;  Li, Shuangyan1;  Wang, Wei1;  Gu, Ruolan3;  Guo, Xin1;  Nan, Xue2;  Ma, Xiaojun1;  Pei, Xuetao2
刊名: TISSUE ENGINEERING PART C-METHODS
发表日期: 2010-10-01
DOI: 10.1089/ten.tec.2009.0374
卷: 16, 期:5, 页:1125-1134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Cell & Tissue Engineering ;  Biotechnology & Applied Microbiology ;  Cell Biology
研究领域[WOS]: Cell Biology ;  Biotechnology & Applied Microbiology
英文摘要: Microencapsulation-mediated cell therapy overcomes the immune incompatibility between donor and recipient in transplantation. The aim of this study was to investigate the effects of transplantation of microcapsules containing a mixture of rat hepatocytes and human fetal liver stromal cells (hFLSCs), engineered to produce basic fibroblast growth factor (bFGF), on acute liver failure (ALF) in mice. In vitro experiments showed that different combinations of microencapsulated rat's hepatocytes and stromal cells survive, grow, and function better in three-dimensional conditions. The metabolic activity of rat hepatocytes co-microencapsulated with hFLSCs, particularly when engineered to produce bFGF (FLSCs/bFGF), is significantly higher than that of microcapsules with rat hepatocytes alone. Intraperitoneal transplantation of the encapsulated hepatocytes with FLSCs/bFGF increased the survival rate and improved liver function of an ALF mouse model induced by a 70% partial hepatectomy in BALB/C mice. Moreover, dramatic liver regeneration was observed 2 days after transplantation in the group that received intraperitoneal transplantations of encapsulated hepatocytes with FLSCs/bFGF. Therefore, transplantation of encapsulated hepatocytes and hFLSCs/bFGF may be a promising strategy to treat ALF or related liver diseases.
关键词[WOS]: ENCAPSULATED XENOGENEIC HEPATOCYTES ;  BIOARTIFICIAL LIVER ;  INTRASPLENIC TRANSPLANTATION ;  IMPROVED SURVIVAL ;  IMMUNIZATION ;  METABOLISM ;  SYSTEM
语种: 英语
WOS记录号: WOS:000282223800032
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141789
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Beijing Inst Transfus Med, Stem Cell & Regenerat Med Lab, Beijing, Peoples R China
3.Beijing Inst Transfus Med, Lab Drug Metab & Pharmacokinet, Beijing, Peoples R China

Recommended Citation:
Teng, Yue,Wang, Yunfang,Li, Shuangyan,et al. Treatment of Acute Hepatic Failure in Mice by Transplantation of Mixed Microencapsulation of Rat Hepatocytes and Transgenic Human Fetal Liver Stromal Cells[J]. TISSUE ENGINEERING PART C-METHODS,2010,16(5):1125-1134.
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