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题名: Chitosan oligosaccharides protect human umbilical vein endothelial cells from hydrogen peroxide-induced apoptosis
作者: Liu, Hong-Tao2, 3;  He, Jun-Lin2;  Li, Wen-Ming2;  Yang, Zhu2;  Wang, Ying-Xiong2;  Bai, Xue-Fang;  Yu, Chao1, 2;  Du, Yu-Guang
关键词: Chitosan oligosaccharides ;  Hydrogen peroxide ;  Apoptosis ;  Human umbilical vein endothelial cell
刊名: CARBOHYDRATE POLYMERS
发表日期: 2010-05-16
DOI: 10.1016/j.carbpol.2010.01.025
卷: 80, 期:4, 页:1062-1071
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: This study aimed to investigate the protective effect of chitosan oligosaccharides (COS) on human umbilical vein endothelial cell (HUVEC) apoptosis induced by hydrogen peroxide (H(2)O(2)). We found that COS not only reversed the decrease of cell viability and proliferation activity, but ameliorated nuclear chromatin damage in H(2)O(2)-induced HUVECs. Additionally, COS contributed to the decrease of cytosolic Ca(2+) level, increase of mitochondrial membrane potential, up-regulation of Bcl-2 mRNA, down-regulation of Bax mRNA, reduction of cleaved caspase-3 protein, inhibition of phosphorylated p38 mitogen-activated protein kinase (MAPK) and induction of phosphorylated Akt in HUVECs. Further, H(2)O(2)-induced caspase-3 activation could be suppressed by p38 MAPK inhibitor (SB203580) and up-regulated by phosphatidylinositol-3-kinase (PI3K) inhibitor (LY294002), indicating the involvement of p38 MAPK and PI3K/Akt signaling pathways. In conclusion, the results show that COS may effectively inhibit the H(2)O(2)-induced HUVEC apoptosis. (C) 2010 Elsevier Ltd. All rights reserved.
关键词[WOS]: OXIDATIVE STRESS ;  HIPPOCAMPAL-NEURONS ;  UP-REGULATION ;  PC12 CELLS ;  IN-VITRO ;  CHITOOLIGOSACCHARIDES ;  DEATH ;  ACTIVATION ;  SURVIVAL ;  BCL-2
语种: 英语
WOS记录号: WOS:000277636200008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141795
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Nat Prod & Glyco Engn Res, Dalian 116023, Peoples R China
2.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 110864, Peoples R China

Recommended Citation:
Liu, Hong-Tao,He, Jun-Lin,Li, Wen-Ming,et al. Chitosan oligosaccharides protect human umbilical vein endothelial cells from hydrogen peroxide-induced apoptosis[J]. CARBOHYDRATE POLYMERS,2010,80(4):1062-1071.
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