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CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes
Cao, Y. -F.1; Zhang, Y. -Y.2,3; Li, J.1; Ge, G. -B.2; Hu, D.1; Liu, H. -X.2,3; Huang, T.1; Wang, Y. -C.1; Fang, Z. -Z.2,3; Sun, D. -X.1; Huo, H.2; Yin, J.1; Yang, L.2
关键词Schizandrin Cytochrome P450 Microsomes Metabolism Fructus Schisandrae
刊名XENOBIOTICA
2010
DOI10.3109/00498250903366052
40期:1页:38-47
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]HUMAN CYTOCHROME-P450 ENZYMES ; MEDROXYPROGESTERONE ACETATE ; IN-VITRO ; METABOLISM ; INHIBITION ; EXTRACT ; FRUIT ; ISOFORMS ; PLASMA ; VIVO
英文摘要1. Schizandrin is recognized as the major absorbed effective constituent of Fructus schisandrae, which is extensively applied in Chinese medicinal formula. The present study aimed to profile the phase I metabolites of schizandrin and identify the cytochrome P450 (CYP) isoforms involved.
语种英语
WOS记录号WOS:000272796100004
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141814
专题中国科学院大连化学物理研究所
作者单位1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
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GB/T 7714
Cao, Y. -F.,Zhang, Y. -Y.,Li, J.,et al. CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes[J]. XENOBIOTICA,2010,40(1):38-47.
APA Cao, Y. -F..,Zhang, Y. -Y..,Li, J..,Ge, G. -B..,Hu, D..,...&Yang, L..(2010).CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes.XENOBIOTICA,40(1),38-47.
MLA Cao, Y. -F.,et al."CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes".XENOBIOTICA 40.1(2010):38-47.
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