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题名: CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes
作者: Cao, Y. -F.1;  Zhang, Y. -Y.2, 3;  Li, J.1;  Ge, G. -B.2;  Hu, D.1;  Liu, H. -X.2, 3;  Huang, T.1;  Wang, Y. -C.1;  Fang, Z. -Z.2, 3;  Sun, D. -X.1;  Huo, H.2;  Yin, J.1;  Yang, L.2
关键词: Schizandrin ;  cytochrome P450 ;  microsomes ;  metabolism ;  Fructus schisandrae
刊名: XENOBIOTICA
发表日期: 2010
DOI: 10.3109/00498250903366052
卷: 40, 期:1, 页:38-47
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: 1. Schizandrin is recognized as the major absorbed effective constituent of Fructus schisandrae, which is extensively applied in Chinese medicinal formula. The present study aimed to profile the phase I metabolites of schizandrin and identify the cytochrome P450 (CYP) isoforms involved.
关键词[WOS]: HUMAN CYTOCHROME-P450 ENZYMES ;  MEDROXYPROGESTERONE ACETATE ;  IN-VITRO ;  METABOLISM ;  INHIBITION ;  EXTRACT ;  FRUIT ;  ISOFORMS ;  PLASMA ;  VIVO
语种: 英语
WOS记录号: WOS:000272796100004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141814
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Cao, Y. -F.,Zhang, Y. -Y.,Li, J.,et al. CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes[J]. XENOBIOTICA,2010,40(1):38-47.
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