DICP OpenIR
CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes
Cao, Y. -F.1; Zhang, Y. -Y.2,3; Li, J.1; Ge, G. -B.2; Hu, D.1; Liu, H. -X.2,3; Huang, T.1; Wang, Y. -C.1; Fang, Z. -Z.2,3; Sun, D. -X.1; Huo, H.2; Yin, J.1; Yang, L.2
KeywordSchizandrin Cytochrome P450 Microsomes Metabolism Fructus Schisandrae
Source PublicationXENOBIOTICA
2010
DOI10.3109/00498250903366052
Volume40Issue:1Pages:38-47
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS KeywordHUMAN CYTOCHROME-P450 ENZYMES ; MEDROXYPROGESTERONE ACETATE ; IN-VITRO ; METABOLISM ; INHIBITION ; EXTRACT ; FRUIT ; ISOFORMS ; PLASMA ; VIVO
Abstract1. Schizandrin is recognized as the major absorbed effective constituent of Fructus schisandrae, which is extensively applied in Chinese medicinal formula. The present study aimed to profile the phase I metabolites of schizandrin and identify the cytochrome P450 (CYP) isoforms involved.
Language英语
WOS IDWOS:000272796100004
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141814
Collection中国科学院大连化学物理研究所
Affiliation1.Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Cao, Y. -F.,Zhang, Y. -Y.,Li, J.,et al. CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes[J]. XENOBIOTICA,2010,40(1):38-47.
APA Cao, Y. -F..,Zhang, Y. -Y..,Li, J..,Ge, G. -B..,Hu, D..,...&Yang, L..(2010).CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes.XENOBIOTICA,40(1),38-47.
MLA Cao, Y. -F.,et al."CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes".XENOBIOTICA 40.1(2010):38-47.
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