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题名: CONVENIENT SYNTHESIS OF OPTICALLY PURE 8-METHOXY-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE AND 2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE
作者: Tang, Jie1;  Jiang, Guo-Fang1;  Zhou, Yong-Gui2
关键词: Chemical Resolution ;  Hydrogenation ;  Chiral Tetrahydroquinoline
刊名: HETEROCYCLES
发表日期: 2010-12-31
DOI: 10.3987/COM-10-S(E)50
卷: 82, 期:1, 页:887-893
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
英文摘要: A convenient method was developed to synthesize optically pure 8-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline (2a) and 2-methyl-1,2,3,4-tetrahydroquinoline (2b) by combining the methods of catalytic hydrogenation and classical resolution. The catalytic system ([Ru(p-cymene)Cl(2)](2)/I(2)) showed high efficiency in preparing racemic 2a and 2b, which were successfully resolved using commercial tartaric acid derivatives, and both enantiomers were obtained in moderate yield with >99% ee.
关键词[WOS]: IRIDIUM-CATALYZED HYDROGENATION ;  ASYMMETRIC HYDROGENATION ;  GALIPEA-OFFICINALIS ;  HETEROAROMATIC-COMPOUNDS ;  KINETIC RESOLUTION ;  QUINOLINES ;  ALKALOIDS ;  (+/-)-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE ;  (+/-)-2-METHYLINDOLINE ;  LIGANDS
语种: 英语
WOS记录号: WOS:000286906100064
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141833
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Tang, Jie,Jiang, Guo-Fang,Zhou, Yong-Gui. CONVENIENT SYNTHESIS OF OPTICALLY PURE 8-METHOXY-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE AND 2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE[J]. HETEROCYCLES,2010,82(1):887-893.
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