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题名: Mutagenicity of acrolein and acrolein-induced DNA adducts
作者: Liu, Xing-yu1, 2;  Zhu, Mao-xiang3;  Xie, Jian-ping2
关键词: Acrolein ;  DNA adduct ;  mutagenicity
刊名: TOXICOLOGY MECHANISMS AND METHODS
发表日期: 2010
DOI: 10.3109/15376510903530845
卷: 20, 期:1, 页:36-44
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
英文摘要: Acrolein mutagenicity relies on DNA adduct formation. Reaction of acrolein with deoxyguanosine generates a-hydroxy-1, N(2)-propano-2'-deoxyguanosine (a-HOPDG) and gamma-hydroxy-1, N(2)-propano-2'-deoxyguanosine (gamma-HOMG) adducts. These two DNA adducts behave differently in mutagenicity. gamma-HOPdG is the major DNA adduct and it can lead to interstrand DNA-DNA and DNA-peptide/protein cross-links, which may induce strong mutagenicity; however, gamma-HOPdG can be repaired by some DNA polymerases complex and lessen its mutagenic effects. a-HOPdG is formed much less than gamma-HOMG, but difficult to be repaired, which contributes to accumulation in vivo. Results of acrolein mutagenicity studies haven't been confirmed, which is mainly due to the conflicting mutagenicity data of the major acrolein adduct (gamma-HOMG). The minor a-HOPdG is mutagenic in both in vitro and in vivo test systems. The role of a-HOPdG in acrolein mutagenicity needs further investigation. The inconsistent result of acrolein mutagenicity can be attributed, at least partially, to a variety of acrolein-DNA adducts formation and their repair in diverse detection systems. Recent results of detection of acrolein-DNA adduct in human lung tissues and analysis of P53 mutation spectra in acrolein-treated cells may shed some light on mechanisms of acrolein mutagenicity. These aspects are covered in this mini review.
关键词[WOS]: HAMSTER OVARY CELLS ;  SISTER-CHROMATID EXCHANGES ;  PEPTIDE CROSS-LINKS ;  DEOXYGUANOSINE ADDUCTS ;  1,N-2-PROPANODEOXYGUANOSINE ADDUCTS ;  ALPHA,BETA-UNSATURATED ALDEHYDES ;  LIPID-PEROXIDATION ;  ESCHERICHIA-COLI ;  OXIDATIVE STRESS ;  1,N(2)-PROPANODEOXYGUANOSINE ADDUCTS
语种: 英语
WOS记录号: WOS:000274406100006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141848
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.CNTC, Zhengzhou Tobacco Res Inst, Zhengzhou 450001, Henan, Peoples R China
3.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China

Recommended Citation:
Liu, Xing-yu,Zhu, Mao-xiang,Xie, Jian-ping. Mutagenicity of acrolein and acrolein-induced DNA adducts[J]. TOXICOLOGY MECHANISMS AND METHODS,2010,20(1):36-44.
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