DICP OpenIR
Mutagenicity of acrolein and acrolein-induced DNA adducts
Liu, Xing-yu1,2; Zhu, Mao-xiang3; Xie, Jian-ping2
KeywordAcrolein Dna Adduct Mutagenicity
Source PublicationTOXICOLOGY MECHANISMS AND METHODS
2010
DOI10.3109/15376510903530845
Volume20Issue:1Pages:36-44
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectToxicology
WOS Research AreaToxicology
WOS KeywordHAMSTER OVARY CELLS ; SISTER-CHROMATID EXCHANGES ; PEPTIDE CROSS-LINKS ; DEOXYGUANOSINE ADDUCTS ; 1,N-2-PROPANODEOXYGUANOSINE ADDUCTS ; ALPHA,BETA-UNSATURATED ALDEHYDES ; LIPID-PEROXIDATION ; ESCHERICHIA-COLI ; OXIDATIVE STRESS ; 1,N(2)-PROPANODEOXYGUANOSINE ADDUCTS
AbstractAcrolein mutagenicity relies on DNA adduct formation. Reaction of acrolein with deoxyguanosine generates a-hydroxy-1, N(2)-propano-2'-deoxyguanosine (a-HOPDG) and gamma-hydroxy-1, N(2)-propano-2'-deoxyguanosine (gamma-HOMG) adducts. These two DNA adducts behave differently in mutagenicity. gamma-HOPdG is the major DNA adduct and it can lead to interstrand DNA-DNA and DNA-peptide/protein cross-links, which may induce strong mutagenicity; however, gamma-HOPdG can be repaired by some DNA polymerases complex and lessen its mutagenic effects. a-HOPdG is formed much less than gamma-HOMG, but difficult to be repaired, which contributes to accumulation in vivo. Results of acrolein mutagenicity studies haven't been confirmed, which is mainly due to the conflicting mutagenicity data of the major acrolein adduct (gamma-HOMG). The minor a-HOPdG is mutagenic in both in vitro and in vivo test systems. The role of a-HOPdG in acrolein mutagenicity needs further investigation. The inconsistent result of acrolein mutagenicity can be attributed, at least partially, to a variety of acrolein-DNA adducts formation and their repair in diverse detection systems. Recent results of detection of acrolein-DNA adduct in human lung tissues and analysis of P53 mutation spectra in acrolein-treated cells may shed some light on mechanisms of acrolein mutagenicity. These aspects are covered in this mini review.
Language英语
WOS IDWOS:000274406100006
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/141848
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.CNTC, Zhengzhou Tobacco Res Inst, Zhengzhou 450001, Henan, Peoples R China
3.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xing-yu,Zhu, Mao-xiang,Xie, Jian-ping. Mutagenicity of acrolein and acrolein-induced DNA adducts[J]. TOXICOLOGY MECHANISMS AND METHODS,2010,20(1):36-44.
APA Liu, Xing-yu,Zhu, Mao-xiang,&Xie, Jian-ping.(2010).Mutagenicity of acrolein and acrolein-induced DNA adducts.TOXICOLOGY MECHANISMS AND METHODS,20(1),36-44.
MLA Liu, Xing-yu,et al."Mutagenicity of acrolein and acrolein-induced DNA adducts".TOXICOLOGY MECHANISMS AND METHODS 20.1(2010):36-44.
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