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题名: Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species
作者: Liu, Hong-Tao1;  Du, Yu-Guang2;  He, Jun-Lin3;  Chen, Wen-Juan1;  Li, Wen-Ming1;  Yang, Zhu1;  Wang, Ying-Xiong1;  Yu, Chao1
关键词: Tetramethylpyrazine ;  Inflammation ;  Inducible nitric oxide synthase ;  Microglial cell ;  Mitogen-activated protein kinase ;  PI3-kinase
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2010-06-16
DOI: 10.1016/j.jep.2010.03.037
卷: 129, 期:3, 页:335-343
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: Aim of the study: To determine the inhibitory effect of tetramethylpyrazine (TMP) on lipopolysaccharide (LPS)-induced over-production of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in N9 microglial cells.
关键词[WOS]: VASCULAR ENDOTHELIAL-CELLS ;  PROTEIN-KINASE PATHWAYS ;  NECROSIS-FACTOR-ALPHA ;  NF-KAPPA-B ;  ACTIVATED MICROGLIA ;  ADHESION MOLECULES ;  INDUCED EXPRESSION ;  INTERFERON-GAMMA ;  GENE-EXPRESSION ;  NADPH OXIDASE
语种: 英语
WOS记录号: WOS:000279439300008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141865
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China

Recommended Citation:
Liu, Hong-Tao,Du, Yu-Guang,He, Jun-Lin,et al. Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species[J]. JOURNAL OF ETHNOPHARMACOLOGY,2010,129(3):335-343.
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