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题名: Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities
作者: Cao, Qing2, 3;  Xu, Yan2;  Liu, Feng3;  Svec, Frantisek1, 2;  Frechet, Jean M. J.1, 2
刊名: ANALYTICAL CHEMISTRY
发表日期: 2010-09-01
DOI: 10.1021/ac1015613
卷: 82, 期:17, 页:7416-7421
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Newly developed porous polymer monolithic capillary columns modified with gold nanoparticles coated with exchangeable functionalities allow easy switching of separation modes by a simple ligand exchange process. These columns are prepared from a poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith through reaction of its epoxide moieties with cysteamine to afford a monolith rich in surface thiol groups. Gold nanoparticles prepared via in situ reduction of chloroauric acid within the column become attached to the surface of the pores of the monolith. Alternatively, a solution of colloidal gold nanoparticles can be pumped through the thiol modified column to achieve their attachment. While the first approach is faster, it affords a lower coverage of nanoparticles than the second method, while both methods preserve the excellent hydrodynamic properties that are typical of the monolithic columns. Functionalization of the surface of the bound gold nanoparticles is then carried out using low molecular weight thiol-containing surface ligands. The dynamic nature of the bond between gold and these surface ligands enables the replacement of one surface ligand by another through a simple solution exchange process. This novel approach expands the application range of monoliths as a single column can now be used in different separations modes. Applications of the columns with exchangeable chemistries are demonstrated with the capillary electrochromatographic separation of peptides and the nano-high-pressure liquid chromatography (HPLC) separation of proteins in both reversed phase and ion exchange modes.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  IONIZATION MASS-SPECTROMETRY ;  TUBULAR GAS-CHROMATOGRAPHY ;  HIGH-FLOW CHARACTERISTICS ;  DOUBLE-STRANDED DNA ;  STATIONARY PHASES ;  POROUS PROPERTIES ;  SEPARATION MEDIUM ;  MACROPOROUS POLYMERS ;  ION CHROMATOGRAPHY
语种: 英语
WOS记录号: WOS:000281306000050
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141867
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.EO Lawrence Berkeley Natl Lab, Mol Foundry, Berkeley, CA 94720 USA
2.Univ Calif Berkeley, Coll Chem, Berkeley, CA 94720 USA
3.Peking Univ, Coll Chem, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Cao, Qing,Xu, Yan,Liu, Feng,et al. Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities[J]. ANALYTICAL CHEMISTRY,2010,82(17):7416-7421.
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