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Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities
Cao, Qing2,3; Xu, Yan2; Liu, Feng3; Svec, Frantisek1,2; Frechet, Jean M. J.1,2
刊名ANALYTICAL CHEMISTRY
2010-09-01
DOI10.1021/ac1015613
82期:17页:7416-7421
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; IONIZATION MASS-SPECTROMETRY ; TUBULAR GAS-CHROMATOGRAPHY ; HIGH-FLOW CHARACTERISTICS ; DOUBLE-STRANDED DNA ; STATIONARY PHASES ; POROUS PROPERTIES ; SEPARATION MEDIUM ; MACROPOROUS POLYMERS ; ION CHROMATOGRAPHY
英文摘要Newly developed porous polymer monolithic capillary columns modified with gold nanoparticles coated with exchangeable functionalities allow easy switching of separation modes by a simple ligand exchange process. These columns are prepared from a poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith through reaction of its epoxide moieties with cysteamine to afford a monolith rich in surface thiol groups. Gold nanoparticles prepared via in situ reduction of chloroauric acid within the column become attached to the surface of the pores of the monolith. Alternatively, a solution of colloidal gold nanoparticles can be pumped through the thiol modified column to achieve their attachment. While the first approach is faster, it affords a lower coverage of nanoparticles than the second method, while both methods preserve the excellent hydrodynamic properties that are typical of the monolithic columns. Functionalization of the surface of the bound gold nanoparticles is then carried out using low molecular weight thiol-containing surface ligands. The dynamic nature of the bond between gold and these surface ligands enables the replacement of one surface ligand by another through a simple solution exchange process. This novel approach expands the application range of monoliths as a single column can now be used in different separations modes. Applications of the columns with exchangeable chemistries are demonstrated with the capillary electrochromatographic separation of peptides and the nano-high-pressure liquid chromatography (HPLC) separation of proteins in both reversed phase and ion exchange modes.
语种英语
WOS记录号WOS:000281306000050
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141867
专题中国科学院大连化学物理研究所
作者单位1.EO Lawrence Berkeley Natl Lab, Mol Foundry, Berkeley, CA 94720 USA
2.Univ Calif Berkeley, Coll Chem, Berkeley, CA 94720 USA
3.Peking Univ, Coll Chem, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci,Minist Educ, Beijing 100871, Peoples R China
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GB/T 7714
Cao, Qing,Xu, Yan,Liu, Feng,et al. Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities[J]. ANALYTICAL CHEMISTRY,2010,82(17):7416-7421.
APA Cao, Qing,Xu, Yan,Liu, Feng,Svec, Frantisek,&Frechet, Jean M. J..(2010).Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities.ANALYTICAL CHEMISTRY,82(17),7416-7421.
MLA Cao, Qing,et al."Polymer Monoliths with Exchangeable Chemistries: Use of Gold Nanoparticles As Intermediate Ligands for Capillary Columns with Varying Surface Functionalities".ANALYTICAL CHEMISTRY 82.17(2010):7416-7421.
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