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Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin
Zhou, Huofei2,3; Yu, Weiting2; Guo, Xin2; Liu, Xiudong1; Li, Nan2; Zhang, Ying2; Ma, Xiaojun2
刊名BIOMACROMOLECULES
2010-12-01
DOI10.1021/bm100989x
11期:12页:3480-3486
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]POLYMERIC MICELLES ; INSULIN DELIVERY ; PLASMID DNA ; DERIVATIVES ; PACLITAXEL ; COMPLEXES ; SYSTEMS ; GENE
英文摘要Novel amphiphilic chitosan derivatives (glycidol chitosan deoxycholic acid, G-CS-DCA) were synthesized by grafting hydrophobic moieties, deoxycholic acid (DCA), and hydrophilic moieties, glycidol, with the purpose of preparing carriers for poorly soluble drugs. Based on self-assembly. G-CS-DCA can form nanoparticles with size ranging from 160 to 210 nm, and G-CS-DCA nanoparticles maintained stable structure for about 3 months when stored in PBS (pH 7.4) at room temperature. The critical aggregation concentration decreased from 0.043 mg/mL to 0.013 mg/mL with the increase of degree of substitution (DS) of DCA. Doxorubicin (DOX) could be easily encapsulated into G-CS-DCA nanoparticles and keep a sustained release manner without burst release when exposed to PBS (pH 7.4) at 37 degrees C. Antitumor efficacy results showed that DOX-G-CS-DCA have significant antitumor activity when MCF-7 cells were incubated with different concentration of DOX-G-CS-DCA nanoparticles. The fluorescence imaging results indicated DOX-G-CS-DCA nanoparticles could easily be uptaken by MCF-7 cells. These results suggested that G-CS-DCA nanoparticles may be a promising carrier for DOX delivery in cancer therapy.
语种英语
WOS记录号WOS:000285267500031
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141877
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Zhou, Huofei,Yu, Weiting,Guo, Xin,et al. Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin[J]. BIOMACROMOLECULES,2010,11(12):3480-3486.
APA Zhou, Huofei.,Yu, Weiting.,Guo, Xin.,Liu, Xiudong.,Li, Nan.,...&Ma, Xiaojun.(2010).Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin.BIOMACROMOLECULES,11(12),3480-3486.
MLA Zhou, Huofei,et al."Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin".BIOMACROMOLECULES 11.12(2010):3480-3486.
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