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题名: Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin
作者: Zhou, Huofei2, 3;  Yu, Weiting2;  Guo, Xin2;  Liu, Xiudong1;  Li, Nan2;  Zhang, Ying2;  Ma, Xiaojun2
刊名: BIOMACROMOLECULES
发表日期: 2010-12-01
DOI: 10.1021/bm100989x
卷: 11, 期:12, 页:3480-3486
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Polymer Science
英文摘要: Novel amphiphilic chitosan derivatives (glycidol chitosan deoxycholic acid, G-CS-DCA) were synthesized by grafting hydrophobic moieties, deoxycholic acid (DCA), and hydrophilic moieties, glycidol, with the purpose of preparing carriers for poorly soluble drugs. Based on self-assembly. G-CS-DCA can form nanoparticles with size ranging from 160 to 210 nm, and G-CS-DCA nanoparticles maintained stable structure for about 3 months when stored in PBS (pH 7.4) at room temperature. The critical aggregation concentration decreased from 0.043 mg/mL to 0.013 mg/mL with the increase of degree of substitution (DS) of DCA. Doxorubicin (DOX) could be easily encapsulated into G-CS-DCA nanoparticles and keep a sustained release manner without burst release when exposed to PBS (pH 7.4) at 37 degrees C. Antitumor efficacy results showed that DOX-G-CS-DCA have significant antitumor activity when MCF-7 cells were incubated with different concentration of DOX-G-CS-DCA nanoparticles. The fluorescence imaging results indicated DOX-G-CS-DCA nanoparticles could easily be uptaken by MCF-7 cells. These results suggested that G-CS-DCA nanoparticles may be a promising carrier for DOX delivery in cancer therapy.
关键词[WOS]: POLYMERIC MICELLES ;  INSULIN DELIVERY ;  PLASMID DNA ;  DERIVATIVES ;  PACLITAXEL ;  COMPLEXES ;  SYSTEMS ;  GENE
语种: 英语
WOS记录号: WOS:000285267500031
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141877
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Zhou, Huofei,Yu, Weiting,Guo, Xin,et al. Synthesis and Characterization of Amphiphilic Glycidol-Chitosan-Deoxycholic Acid Nanoparticles as a Drug Carrier for Doxorubicin[J]. BIOMACROMOLECULES,2010,11(12):3480-3486.
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