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Determination of diketopiperazines of Burkholderia cepacia CF-66 by gas chromatography-mass spectrometry
Wang, Jian-Hua2,3; Quan, Chun-Shan1; Qi, Xiao-Hui1; Li, Xin2,3; Fan, Sheng-Di1
关键词Quorum Sensing Signal Molecules Burkholderia Cepacia Cf-66 Gas Chromatography-mass Spectrometry Polymerase Chain Reaction Diketopiperazines
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2010-03-01
DOI10.1007/s00216-009-3379-3
396期:5页:1773-1779
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]LACTONE SIGNAL MOLECULES ; GRAM-NEGATIVE BACTERIA ; PSEUDOMONAS-AERUGINOSA ; HOMOSERINE LACTONES ; ANTIFUNGAL ACTIVITY ; CYCLIC DIPEPTIDES ; CROSS-TALK ; QUORUM ; IDENTIFICATION ; COMMUNICATION
英文摘要Bacteria communicate with each other by a process termed "quorum sensing" (QS), and diffusible, low-molecular-weight chemicals, called signal molecules, are used as the communication languages. In cell-free Burkholderia cepacia CF-66 culture supernatants, five compounds suspected of being signal molecules were identified. The gene (cepI) related with AHLs synthesis were not detected by polymerase chain reaction (PCR) using specific primers. Gas chromatography-mass spectrometry (GC-MS) revealed that these compounds were not AHLs but the diketopiperazines (DKPs) cyclo(ProPhe), cyclo(Pro-Tyr), cyclo(Ala-Val), cyclo(Pro-Leu), and cyclo(Pro-Val), all of which were both D and L-type. Four kinds of DKPs had been isolated from other Gramnegative bacteria, but the other was a novel kind discovered in CF-66, and L-cyclo (Pro-Phe) was quantified by GC-MS. It was found that exogenous DKPs had a negative effect on the candidacidal activity of the culture supernatant extracts.
语种英语
WOS记录号WOS:000274742900019
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141878
专题中国科学院大连化学物理研究所
作者单位1.Dalian Nationalities Univ, Life Sci Coll, Dalian 116600, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Wang, Jian-Hua,Quan, Chun-Shan,Qi, Xiao-Hui,et al. Determination of diketopiperazines of Burkholderia cepacia CF-66 by gas chromatography-mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2010,396(5):1773-1779.
APA Wang, Jian-Hua,Quan, Chun-Shan,Qi, Xiao-Hui,Li, Xin,&Fan, Sheng-Di.(2010).Determination of diketopiperazines of Burkholderia cepacia CF-66 by gas chromatography-mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,396(5),1773-1779.
MLA Wang, Jian-Hua,et al."Determination of diketopiperazines of Burkholderia cepacia CF-66 by gas chromatography-mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 396.5(2010):1773-1779.
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