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题名: Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27
作者: Yan, Jian;  Sun, Lirong;  Li, Wei;  Zhou, Lin;  Li, Zhongrong;  Zhang, Xianmin;  Yang, Ling;  Qiu, Minghua1
关键词: Lycopodiaceae ;  Diphasiastrum complanatum ;  serratane-type ;  complanatumols A-D ;  leukemia
刊名: PLANTA MEDICA
发表日期: 2010-03-01
DOI: 10.1055/s-0029-1186168
卷: 76, 期:4, 页:353-357
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: Four serratane-type triterpenes (1-4) were isolated from D. complanatum. Their chemical structures were elucidated as 14 alpha, 15 alpha, 20 beta, 21 beta, 24, 27 alpha,29-heptahydroxyserrat-3-one (1), 3 beta, 14 alpha, 15 alpha,20 beta,21 beta,24,27 alpha, 29-octahydroxyserratane (2), 3 alpha,14 alpha,20 beta,21 beta,24,27 beta, 29-heptahydroxyserratane (3) and 3 beta,14 alpha,21 beta,24,27 beta-pentahydroxylserratane-29-yl (E)-p-coumarate (4) by spectroscopic methods (MS, 1D and 2D NMR) and X-ray crystallography. Interestingly, the most characteristic methylene (C-27) of the serratane ring C was oxidized to a methine. Compound 4 showed significant cytotoxic activity against the human leukemia K562/S and the doxorubicin-resistant K562/R cell lines, but the other compounds were inactive.
关键词[WOS]: HUPERZIA-SERRATA ;  PICEA-JEZOENSIS ;  LYCOPODIUM ;  ASSAY ;  BARK
语种: 英语
WOS记录号: WOS:000275033200008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141880
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, S China Bot Garden, Guangzhou, Guangdong, Peoples R China
3.So Med Univ, Sch Basic Med Sci, Guangzhou, Guangdong, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resources Discovery, Dalian, Peoples R China

Recommended Citation:
Yan, Jian,Sun, Lirong,Li, Wei,et al. Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27[J]. PLANTA MEDICA,2010,76(4):353-357.
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