中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Low Temperature Heat Capacity and Thermal Analysis of Caffeine, Theophylline and Aminophylline
作者: Xu Fen1, 2;  Qiu Shu-Jun4;  Liang Jian-Guo3;  Wu Rui-Hua4;  Sun Li-Xian1;  Li Fen1
关键词: Low temperature heat capacity ;  Caffeine ;  Theophylline ;  Aminophylline ;  Thermal analysis
刊名: ACTA PHYSICO-CHIMICA SINICA
发表日期: 2010-08-01
DOI: 10.3866/PKU.WHXB20100836
卷: 26, 期:8, 页:2096-2102
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: Caffeine, theophylline, and aminophylline are important methyl-substituted xanthines and are widely used in clinics. In this work, the thermodynamic characteristics of the three drugs were studied by adiabatic calorimetry, thermogravimetric analysis (TG) and differential scanning calorimetry (DSC). The low temperature molar heat capacities of caffeine (in the. crystal form), theophylline and aminophylline were measured by heating the system from 80 to 370 K using an adiabatic calorimeter. The results indicate that the molar heat capacity of aminophylline is the largest while that of theophylline is the smallest. The experimental molar heat capacities of the three drugs were fitted to a polynomial of C-p,C- m vs the reduced temperature (t) by means of the least fitting square method from 80 to 370 K. Their molar heat capacities at 298.15 K were calculated to be 226.49 J . K-1 . mol(-1) (for caffeine), 218.13 J . K-1 . mol(-1) (for theophylline), and 554.78 J . K-1 . mol(-1) (for aminophylline) using the polynomial C-p,C- m-t. Thermodynamic parameters (such as enthalpies and entropies relative to 298.15 K) were calculated for these drugs based on the polynomial C-p,C- m-t. The results of thermal analysis show that the order of thermal stability for these drugs is aminophylline
关键词[WOS]: THERMODYNAMIC PROPERTIES ;  ANHYDROUS CAFFEINE ;  AQUEOUS-SOLUTIONS ;  ENTHALPY ;  SODIUM ;  ASTHMA
语种: 英语
WOS记录号: WOS:000280259900005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141931
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Liaoning Normal Univ, Coll Chem & Chem Engn, Dalian 116029, Liaoning, Peoples R China
3.Hunan Inst Drug Detect, Changsha 410001, Hunan, Peoples R China
4.Dalian Inst Drug Detect, Dalian 116021, Liaoning, Peoples R China

Recommended Citation:
Xu Fen,Qiu Shu-Jun,Liang Jian-Guo,et al. Low Temperature Heat Capacity and Thermal Analysis of Caffeine, Theophylline and Aminophylline[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(8):2096-2102.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Xu Fen]'s Articles
 [Qiu Shu-Jun]'s Articles
 [Liang Jian-Guo]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Xu Fen]‘s Articles
 [Qiu Shu-Jun]‘s Articles
 [Liang Jian-Guo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace