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Low Temperature Heat Capacity and Thermal Analysis of Caffeine, Theophylline and Aminophylline
Xu Fen1,2; Qiu Shu-Jun4; Liang Jian-Guo3; Wu Rui-Hua4; Sun Li-Xian1; Li Fen1
关键词Low Temperature Heat Capacity Caffeine Theophylline Aminophylline Thermal Analysis
刊名ACTA PHYSICO-CHIMICA SINICA
2010-08-01
DOI10.3866/PKU.WHXB20100836
26期:8页:2096-2102
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]THERMODYNAMIC PROPERTIES ; ANHYDROUS CAFFEINE ; AQUEOUS-SOLUTIONS ; ENTHALPY ; SODIUM ; ASTHMA
英文摘要Caffeine, theophylline, and aminophylline are important methyl-substituted xanthines and are widely used in clinics. In this work, the thermodynamic characteristics of the three drugs were studied by adiabatic calorimetry, thermogravimetric analysis (TG) and differential scanning calorimetry (DSC). The low temperature molar heat capacities of caffeine (in the. crystal form), theophylline and aminophylline were measured by heating the system from 80 to 370 K using an adiabatic calorimeter. The results indicate that the molar heat capacity of aminophylline is the largest while that of theophylline is the smallest. The experimental molar heat capacities of the three drugs were fitted to a polynomial of C-p,C- m vs the reduced temperature (t) by means of the least fitting square method from 80 to 370 K. Their molar heat capacities at 298.15 K were calculated to be 226.49 J . K-1 . mol(-1) (for caffeine), 218.13 J . K-1 . mol(-1) (for theophylline), and 554.78 J . K-1 . mol(-1) (for aminophylline) using the polynomial C-p,C- m-t. Thermodynamic parameters (such as enthalpies and entropies relative to 298.15 K) were calculated for these drugs based on the polynomial C-p,C- m-t. The results of thermal analysis show that the order of thermal stability for these drugs is aminophylline
语种英语
WOS记录号WOS:000280259900005
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141931
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Liaoning Normal Univ, Coll Chem & Chem Engn, Dalian 116029, Liaoning, Peoples R China
3.Hunan Inst Drug Detect, Changsha 410001, Hunan, Peoples R China
4.Dalian Inst Drug Detect, Dalian 116021, Liaoning, Peoples R China
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Xu Fen,Qiu Shu-Jun,Liang Jian-Guo,et al. Low Temperature Heat Capacity and Thermal Analysis of Caffeine, Theophylline and Aminophylline[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(8):2096-2102.
APA Xu Fen,Qiu Shu-Jun,Liang Jian-Guo,Wu Rui-Hua,Sun Li-Xian,&Li Fen.(2010).Low Temperature Heat Capacity and Thermal Analysis of Caffeine, Theophylline and Aminophylline.ACTA PHYSICO-CHIMICA SINICA,26(8),2096-2102.
MLA Xu Fen,et al."Low Temperature Heat Capacity and Thermal Analysis of Caffeine, Theophylline and Aminophylline".ACTA PHYSICO-CHIMICA SINICA 26.8(2010):2096-2102.
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