中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography
作者: Shan, Yichu1, 2;  Zhang, Wei2
关键词: High-performance centrifugal partition chromatography ;  alpha-Mangostin ;  gamma-Mangostin ;  Mangosteen fruit pericarp ;  Xanthones
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2010-05-01
DOI: 10.1002/jssc.200900774
卷: 33, 期:9, 页:1274-1278
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Mangosteen fruit pericarp (MFP) is a rich source of xanthones, which has shown remarkable pharmacological activities. To isolate xanthones, previous methods included labor intensive and time-consuming solid-phase extractions (Sephadex LH20, silica gel) and sequential solvent extraction. In this study, major xanthones (alpha- and gamma-mangostins) in MFP were isolated at high purity in one step utilizing high-performance centrifugal partition chromatography with solvent system composed of petroleum ether, ethyl acetate, methanol and water (10:5:5:1). In one run, 200 mg crude extract of MFP was injected and 55.4 mg alpha-mangostin and 12.4 mg gamma-mangostin were obtained with the purity of 93.6 and 98.4%, respectively. The yields of them were 86.3 and 76.3%, respectively. As alpha- and gamma-mangostins are reported to show potent antioxidant, anti-inflammatory and anticancer activities, this method can be used for the large-scale production of them for future in vitro and in vivo biological studies.
关键词[WOS]: COUNTER-CURRENT CHROMATOGRAPHY ;  MEDICINAL-PLANT EXTRACTS ;  GARCINIA-MANGOSTANA ;  ALPHA-MANGOSTIN ;  CELL-LINES ;  PURIFICATION ;  APOPTOSIS ;  INDUCTION ;  FRUIT ;  HPLC
语种: 英语
WOS记录号: WOS:000277938200012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141936
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, CAS Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
2.Flinders Univ S Australia, Mol Bioproc & Bioprod Lab, Dept Med Biotechnol, Sch Med, Adelaide, SA 5001, Australia

Recommended Citation:
Shan, Yichu,Zhang, Wei. Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2010,33(9):1274-1278.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Shan, Yichu]'s Articles
 [Zhang, Wei]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Shan, Yichu]‘s Articles
 [Zhang, Wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace