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题名: Chitosan oligosaccharides suppressant LPS binding to TLR4/MD-2 receptor complex
作者: Qiao, Ying1, 2;  Ruan, Yuanyuan3;  Xiong, Chuannan1;  Xu, Qingsong1;  Wei, Peng1;  Ma, Pan1;  Bai, Xuefang1;  Du, Yuguang1
关键词: LPS ;  IL-1 beta ;  Chitosan oligosaccharides ;  MAPKs ;  NF-kappa B ;  Binding
刊名: CARBOHYDRATE POLYMERS
发表日期: 2010-09-05
DOI: 10.1016/j.carbpol.2010.04.079
卷: 82, 期:2, 页:405-411
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: Lipopolysaccharide, a potent activator of the immune system, elicits the production of pro-inflammatory mediators in immunocytes. Toll-like receptor 4 (TLR4) and myeloid differentiation factor (MD) 2 receptor complex is required for recognition and signaling of LPS. Previous study suggested water soluble chitosan decreased secretion of pro-inflammatory cytokines TNF-alpha and IL-6. However, no studies have provided direct target and molecular mechanism of anti-inflammatory effect of chitosan oligosaccharide on LPS-stimulated cells. In this study, we found that chitosan oligosaccharides significantly inhibited binding of LPS to TLR4/MD-2 receptor complex, thus attenuated activation of mitogen-activated protein kinases (MAPKs) and decreased nuclear translocation of nuclear factor-kappa B (NF-kappa B). Finally, chitosan oligosaccharides reduced the production of pro-inflammatory mediator, such as IL-1 beta and nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. Therefore, chitosan oligosaccharides are potential inhibitive effector of LPS. (C) 2010 Elsevier Ltd. All rights reserved.
关键词[WOS]: RADICAL SCAVENGING ACTIVITY ;  NF-KAPPA-B ;  SEPTIC SHOCK ;  IN-VITRO ;  LIPOPOLYSACCHARIDE-BINDING ;  TLR4-MD-2 COMPLEX ;  MOLECULAR-WEIGHT ;  GENE-EXPRESSION ;  CHITOOLIGOSACCHARIDES ;  PROTEIN
语种: 英语
WOS记录号: WOS:000280574600026
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141958
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dept Biotechnol, Dalian 116023, Liaoning, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Fudan Univ, Shanghai Med Coll, Ctr Gene Res, Shanghai 200032, Peoples R China

Recommended Citation:
Qiao, Ying,Ruan, Yuanyuan,Xiong, Chuannan,et al. Chitosan oligosaccharides suppressant LPS binding to TLR4/MD-2 receptor complex[J]. CARBOHYDRATE POLYMERS,2010,82(2):405-411.
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