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题名: Chitooligosaccharides inhibit nitric oxide mediated migration of endothelial cells in vitro and tumor angiogenesis in vivo
作者: Wu, Haige1, 2;  Yao, Ziang2;  Bai, Xuefang1;  Du, Yuguang1;  Ma, Xiaojun1
关键词: Chitooligosaccharides ;  Endothelial cell ;  Migration ;  Angiogenesis ;  NO
刊名: CARBOHYDRATE POLYMERS
发表日期: 2010-10-15
DOI: 10.1016/j.carbpol.2010.06.015
卷: 82, 期:3, 页:927-932
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: Chitooligosaccharides (COS), with a polymerization degree of 2-8, were prepared by the enzymic hydrolysis of chitosan. The anti-angiogenic activity of COS in subcutaneous xenografts in mice has been studied for the first time. As nitric oxide (NO) plays a critical role in angiogenesis, we investigated the relationship between COS and the NO-mediated migration of endothelial cells. The results demonstrated that COS could suppress tumor angiogenesis and exhibit antioxidant activity by increasing the SOD activity in Kunming mice that were implanted with human breast cancer cells, dose-dependently. COS was able to inhibit the migration of endothelial cells induced by NO. In addition, COS altered the polymerization of actin and antagonized the formation of membrane extensions that were triggered by NO in endothelial cells. Together, these results indicated that COS had anti-angiogenic activity in vivo and in vitro, and the inhibitory activity of COS on endothelial cell migration may be due to interference with the NO signal transduction pathway. (C) 2010 Elsevier Ltd. All rights reserved.
关键词[WOS]: FIBROBLAST-GROWTH-FACTOR ;  CHITOSAN ;  SYNTHASE
语种: 英语
WOS记录号: WOS:000281524900058
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141970
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China

Recommended Citation:
Wu, Haige,Yao, Ziang,Bai, Xuefang,et al. Chitooligosaccharides inhibit nitric oxide mediated migration of endothelial cells in vitro and tumor angiogenesis in vivo[J]. CARBOHYDRATE POLYMERS,2010,82(3):927-932.
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