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题名: Inhibitory study of two cephalosporins on E. coli by microcalorimetry
作者: Yang, L. N.1, 2;  Sun, Li Xian1;  Xu, Fen3;  Zhang, J.1;  Zhao, J. N.1;  Zhao, Z. B.4;  Song, C. G.5;  Wu, R. H.5;  Ozao, Riko6
关键词: Cefpiramide ;  Ceftizoxime sodium ;  Cephalosporins ;  E. coli DH5 alpha ;  Metabolism ;  Inhibition ;  Microcalorimetry
刊名: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
发表日期: 2010-05-01
DOI: 10.1007/s10973-009-0222-1
卷: 100, 期:2, 页:589-592
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical ;  Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: The microcalorimetric method has been used to study the effects of cefpiramide and ceftizoxime sodium on the E. coli growth. The results revealed that these two cephalosporins may alter the metabolic way of the E. coli. Moreover, the lethal doses of cefpiramide and ceftizoxime sodium are 2.000 and 0.2000 mu g mL(-1), respectively. Combining with the relationships between growth rate constant (k), the maximum power output (P (m) ), the time corresponding to the maximum power output (t (m) ) and cephalosporins concentration (C), one can draw the conclusion that the ceftizoxime sodium has a stronger inhibition effects on the growth of E. coli than that of cefpiramide and they both have the possibility to induce the drug fever.
关键词[WOS]: TOXIC ACTION ;  GROWTH ;  METABOLISM ;  TISSUE ;  ANTIBIOTICS ;  CEFPIRAMIDE ;  DH5-ALPHA ;  CR(VI)
语种: 英语
WOS记录号: WOS:000276771600028
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141981
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Mat & Thermochem Lab, Dalian 116023, Peoples R China
2.Zunyi Normal Coll, Dept Chem, Zunyi 563002, Peoples R China
3.Liaoning Normal Univ, Coll Chem & Chem Engn, Dalian 116029, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
5.Dalian Inst Drug Detect, Dalian 116021, Peoples R China
6.Sony Corp, Inst Higher Educ, Kanagawa 2438501, Japan

Recommended Citation:
Yang, L. N.,Sun, Li Xian,Xu, Fen,et al. Inhibitory study of two cephalosporins on E. coli by microcalorimetry[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,2010,100(2):589-592.
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