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题名: Chitosan oligosaccharides inhibit TNF-alpha-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways
作者: Liu, Hong-Tao1, 2, 3;  Li, Wen-Ming1;  Huang, Pei1;  Chen, Wen-Juan1;  Liu, Qi-Shun2;  Bai, Xue-Fang2;  Yu, Chao1;  Du, Yu-Guang2
关键词: Chitosan oligosaccharides ;  Vascular cell adhesion molecule-1 ;  Intercellular adhesion molecule-1 ;  Tumor necrosis factor-alpha ;  Mitogen-activated protein kinases ;  Human umbilical vein endothelial cells
刊名: CARBOHYDRATE POLYMERS
发表日期: 2010-05-23
DOI: 10.1016/j.carbpol.2010.01.054
卷: 81, 期:1, 页:49-56
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: This study aimed to investigate the inhibitive effects of chitosan oligosaccharides (COS) on tumor necrosis factor (TNF)-alpha-induced over-expression of vascular adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs). We found that COS effectively inhibited TNF-alpha-induced expression of VCAM-1 and ICAM-1 at the level of transcription and translation. Signal transduction studies suggested that COS blocked TNF-alpha-induced activation of NF-kappa B, degradation of I kappa B alpha, and phosphorylation of p38 MAPK and ERK1/2. A further investigation showed that the NF-kappa B activation can be partly suppressed by p38 MAPK inhibitor (58203580) and ERK1/2 inhibitor (PD98059), which also ameliorated the mRNA expression of VCAM-1 and ICAM-1 in TNF-alpha-induced HUVECs. Additionally, COS decreased U937 monocyte adhesion to HUVECs induced by TNF-alpha. Our findings suggest that COS inhibit VCAM-1 and ICAM-1 production in activated HUVECs at least partly through the blockade of p38 and ERK1/2 signaling pathways. (C) 2010 Elsevier Ltd. All rights reserved.
关键词[WOS]: NF-KAPPA-B ;  INTERCELLULAR-ADHESION MOLECULE-1 ;  NITRIC-OXIDE PRODUCTION ;  SMOOTH-MUSCLE-CELLS ;  MAP KINASE ;  IN-VITRO ;  CHITOOLIGOSACCHARIDES ;  ACTIVATION ;  MACROPHAGES ;  COS
语种: 英语
WOS记录号: WOS:000277953500008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141985
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Nat Prod & Glycoengn Res, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 110864, Peoples R China

Recommended Citation:
Liu, Hong-Tao,Li, Wen-Ming,Huang, Pei,et al. Chitosan oligosaccharides inhibit TNF-alpha-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways[J]. CARBOHYDRATE POLYMERS,2010,81(1):49-56.
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