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题名: Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives
作者: Zhou, Huo-Fei2, 3;  Liu, Xiu-Dong1;  Zhang, Ying2;  Ma, Xiao-Jun2
关键词: Chitosan ;  Lithocholic Acid ;  Quaternization ;  Nanoaggregates
刊名: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
发表日期: 2010-04-01
DOI: 10.1166/jnn.2010.2163
卷: 10, 期:4, 页:2304-2313
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Multidisciplinary ;  Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary ;  Physics, Applied ;  Physics, Condensed Matter
研究领域[WOS]: Chemistry ;  Science & Technology - Other Topics ;  Materials Science ;  Physics
英文摘要: A novel kind of chitosan derivatives (CS-LA-TM) were synthesized by grafting hydrophobic molecules of lithocholic acid (LA) and quaternization. CS-LA-TM and micelle-like self-aggregates were characterized by FTIR, (1)H NMR, fluorescence spectroscopy, dynamic light scattering, and transmission electron microscopy (TEM). The critical micelles concentration (CMC) ranging from 0.009 mg/mL to 0.030 mg/mL decreased with increasing of the degree of substitution (DS) of LA, pH of medium but with decreasing of the degree of quaternization (DQ) of amino groups. The TEM images demonstrated that spherical CS-LA-TM nanoaggregates with uniform size were formed by self-assembly. The sizes (100-200 nm) of CS-LAs-TMs nanoaggregates increased with increasing of DS, DO, and can be easily controlled by pH of medium, which may confer the nanoaggregates potential as delivery systems for anticancer drugs, or DNA and siRNA.
关键词[WOS]: DRUG-DELIVERY ;  AGGREGATED NANOPARTICLES ;  POLYMERIC MICELLES ;  BLOCK-COPOLYMER ;  GENE CARRIER ;  IN-VITRO ;  SYSTEMS ;  PACLITAXEL ;  CYTOTOXICITY ;  RELEASE
语种: 英语
WOS记录号: WOS:000273984900005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141988
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Zhou, Huo-Fei,Liu, Xiu-Dong,Zhang, Ying,et al. Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(4):2304-2313.
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