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Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives
Zhou, Huo-Fei2,3; Liu, Xiu-Dong1; Zhang, Ying2; Ma, Xiao-Jun2
关键词Chitosan Lithocholic Acid Quaternization Nanoaggregates
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2010-04-01
DOI10.1166/jnn.2010.2163
10期:4页:2304-2313
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]DRUG-DELIVERY ; AGGREGATED NANOPARTICLES ; POLYMERIC MICELLES ; BLOCK-COPOLYMER ; GENE CARRIER ; IN-VITRO ; SYSTEMS ; PACLITAXEL ; CYTOTOXICITY ; RELEASE
英文摘要A novel kind of chitosan derivatives (CS-LA-TM) were synthesized by grafting hydrophobic molecules of lithocholic acid (LA) and quaternization. CS-LA-TM and micelle-like self-aggregates were characterized by FTIR, (1)H NMR, fluorescence spectroscopy, dynamic light scattering, and transmission electron microscopy (TEM). The critical micelles concentration (CMC) ranging from 0.009 mg/mL to 0.030 mg/mL decreased with increasing of the degree of substitution (DS) of LA, pH of medium but with decreasing of the degree of quaternization (DQ) of amino groups. The TEM images demonstrated that spherical CS-LA-TM nanoaggregates with uniform size were formed by self-assembly. The sizes (100-200 nm) of CS-LAs-TMs nanoaggregates increased with increasing of DS, DO, and can be easily controlled by pH of medium, which may confer the nanoaggregates potential as delivery systems for anticancer drugs, or DNA and siRNA.
语种英语
WOS记录号WOS:000273984900005
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/141988
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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GB/T 7714
Zhou, Huo-Fei,Liu, Xiu-Dong,Zhang, Ying,et al. Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(4):2304-2313.
APA Zhou, Huo-Fei,Liu, Xiu-Dong,Zhang, Ying,&Ma, Xiao-Jun.(2010).Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(4),2304-2313.
MLA Zhou, Huo-Fei,et al."Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.4(2010):2304-2313.
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