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题名: Effects of exogenous methyl jasmonate on artemisinin biosynthesis and secondary metabolites in Artemisia annua L.
作者: Wang, Huahong1, 4;  Ma, Chenfei2;  Li, Zhenqiu3;  Ma, Lanqing1;  Wang, Hong1;  Ye, Hechun1;  Xu, Guowang2;  Liu, Benye1
关键词: Artemisia annua L. ;  GC-MS ;  Artemisinin ;  Metabolite profiling ;  Methyl jasmonate
刊名: INDUSTRIAL CROPS AND PRODUCTS
发表日期: 2010-03-01
DOI: 10.1016/j.indcrop.2009.10.008
卷: 31, 期:2, 页:214-218
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Agricultural Engineering ;  Agronomy
研究领域[WOS]: Agriculture
英文摘要: Artemisin is a sesquiterpene lactone with an endoperoxide bridge first isolated from the aerial parts of Artemisia annua L (Compositae). It is an important antimalarial component, but as of present remains quite expensive due to its low content in the plant, the only commercial source of the compound. In this study, we found a 49% increase of the artemisinin content in A. annua SP18 on day 8 after treatment with methyl jasmonate (MeJA), together with an 80% increase in artemisinic acid and 28% in dihydroartemisinic acid, the two potential precursors of artemisinin. In addition, the effects of exogenous MeJA on other secondary metabolites were evaluated by metabolite profiling using orthogonal signal correction partial least square discriminant analysis (OSC-PLS). Six sesquiterpenoids and three triterpenoids were selected as marker compounds in OSC-PLS. Their content also changed significantly after MeJA treatment, including a 50% increase in methyl artemisinic acid, a 67% increase in squalene and a 60% increase in peak 51 (an unidentified sesquiterpenoid). These compounds are promising targets for further studies on artemisinin biosynthesis and metabolic engineering. (C) 2009 Elsevier B.V. All rights reserved.
关键词[WOS]: VOLATILE TERPENE BIOSYNTHESIS ;  ANTIMALARIAL-DRUG ;  GLANDULAR TRICHOMES ;  INDUCTION ;  ACID ;  CULTURES ;  FOLIAGE ;  PLANTS
语种: 英语
WOS记录号: WOS:000275972700003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/141992
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Photosynth & Environm Mol Physiol, Inst Bot, Beijing 100093, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
3.Hebei Univ, Coll Life Sci, Baoding 071002, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Wang, Huahong,Ma, Chenfei,Li, Zhenqiu,et al. Effects of exogenous methyl jasmonate on artemisinin biosynthesis and secondary metabolites in Artemisia annua L.[J]. INDUSTRIAL CROPS AND PRODUCTS,2010,31(2):214-218.
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