DICP OpenIR
Spray-spinning: a novel method for making alginate/chitosan fibrous scaffold
Wang, Jian-Zheng1,2; Huang, Xiao-Bo1,2; Xiao, Jing1,2; Li, Nan1,2; Yu, Wei-Ting1; Wang, Wei1; Xie, Wei-Yang1; Ma, Xiao-Jun1; Teng, Ying-Li3
Source PublicationJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
2010-02-01
DOI10.1007/s10856-009-3867-1
Volume21Issue:2Pages:497-506
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS Research AreaEngineering ; Materials Science
WOS KeywordCHITOSAN-ALGINATE ; CROSS-LINKING ; HYBRID SCAFFOLDS ; SODIUM ALGINATE ; FIBER ; NANOFIBERS ; SYSTEM ; CARTILAGE ; OXIDE) ; ACID
AbstractThe subject of our investigations was the process of obtaining alginate/chitosan polyelectrolyte complex (PEC) fibers. In this study, a novel method named "spray-spinning" was developed for the making of these hybrid fibers. In spray-spinning, a chitosan solution was sprayed into a flowing sodium alginate solution and sheared into streamlines. The elongated streamlines subsequently transformed into alginate/chitosan PEC fibers. Average diameter of the fibers increased with the increasing of chitosan concentration used in spinning. The fibers showed a high water-absorbability of about 45 folds of water to their dry weight and retained their integrity after incubation in Minimum Essential Medium (MEM) for up to 30 days. In vitro co-culture experiments indicated that the fibers could support the three-dimensional growth of HepG2 cells and did not display any cyto-toxicity. Moreover, in vivo implanting experiments indicated that the connective tissue cells infiltrated into the implanted fibrous scaffolds in 3 weeks after surgery. These results demonstrated the potential applications of the as-spun fibers in regenerative medicine and tissue engineering.
Language英语
WOS IDWOS:000274436300014
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142009
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Dalian Jiaotong Univ, Sch Mat Sci & Engn, Dalian 116028, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jian-Zheng,Huang, Xiao-Bo,Xiao, Jing,et al. Spray-spinning: a novel method for making alginate/chitosan fibrous scaffold[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2010,21(2):497-506.
APA Wang, Jian-Zheng.,Huang, Xiao-Bo.,Xiao, Jing.,Li, Nan.,Yu, Wei-Ting.,...&Teng, Ying-Li.(2010).Spray-spinning: a novel method for making alginate/chitosan fibrous scaffold.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,21(2),497-506.
MLA Wang, Jian-Zheng,et al."Spray-spinning: a novel method for making alginate/chitosan fibrous scaffold".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 21.2(2010):497-506.
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