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题名: Spray-spinning: a novel method for making alginate/chitosan fibrous scaffold
作者: Wang, Jian-Zheng1, 2;  Huang, Xiao-Bo1, 2;  Xiao, Jing1, 2;  Li, Nan1, 2;  Yu, Wei-Ting1;  Wang, Wei1;  Xie, Wei-Yang1;  Ma, Xiao-Jun1;  Teng, Ying-Li3
刊名: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
发表日期: 2010-02-01
DOI: 10.1007/s10856-009-3867-1
卷: 21, 期:2, 页:497-506
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Biomedical ;  Materials Science, Biomaterials
研究领域[WOS]: Engineering ;  Materials Science
英文摘要: The subject of our investigations was the process of obtaining alginate/chitosan polyelectrolyte complex (PEC) fibers. In this study, a novel method named "spray-spinning" was developed for the making of these hybrid fibers. In spray-spinning, a chitosan solution was sprayed into a flowing sodium alginate solution and sheared into streamlines. The elongated streamlines subsequently transformed into alginate/chitosan PEC fibers. Average diameter of the fibers increased with the increasing of chitosan concentration used in spinning. The fibers showed a high water-absorbability of about 45 folds of water to their dry weight and retained their integrity after incubation in Minimum Essential Medium (MEM) for up to 30 days. In vitro co-culture experiments indicated that the fibers could support the three-dimensional growth of HepG2 cells and did not display any cyto-toxicity. Moreover, in vivo implanting experiments indicated that the connective tissue cells infiltrated into the implanted fibrous scaffolds in 3 weeks after surgery. These results demonstrated the potential applications of the as-spun fibers in regenerative medicine and tissue engineering.
关键词[WOS]: CHITOSAN-ALGINATE ;  CROSS-LINKING ;  HYBRID SCAFFOLDS ;  SODIUM ALGINATE ;  FIBER ;  NANOFIBERS ;  SYSTEM ;  CARTILAGE ;  OXIDE) ;  ACID
语种: 英语
WOS记录号: WOS:000274436300014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142009
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Dalian Jiaotong Univ, Sch Mat Sci & Engn, Dalian 116028, Peoples R China

Recommended Citation:
Wang, Jian-Zheng,Huang, Xiao-Bo,Xiao, Jing,et al. Spray-spinning: a novel method for making alginate/chitosan fibrous scaffold[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2010,21(2):497-506.
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