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Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits
Zhao, Xinjie1; Fritsche, Jens2; Wang, Jiangshan1; Chen, Jing1; Rittig, Kilian4; Schmitt-Kopplin, Philippe5; Fritsche, Andreas4; Haering, Hans-Ulrich4; Schleicher, Erwin D.3; Xu, Guowang1; Lehmann, Rainer3
KeywordMetabolomics Uplc-qtof-ms Diabetes Pre-diabetes Impaired Glucose Tolerance
Source PublicationMETABOLOMICS
2010-09-01
DOI10.1007/s11306-010-0203-1
Volume6Issue:3Pages:362-374
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectEndocrinology & Metabolism
WOS Research AreaEndocrinology & Metabolism
WOS KeywordIMPAIRED GLUCOSE-TOLERANCE ; DIABETES-MELLITUS PATIENTS ; FA/FA OBESE RATS ; INSULIN-RESISTANCE ; MASS-SPECTROMETRY ; ENDOTHELIAL-CELLS ; SYSTEMS BIOLOGY ; GUT MICROBIOME ; FATTY LIVER ; DISEASE
AbstractImpaired glucose tolerance (IGT) which precedes overt type 2 diabetes (T2DM) for decades is associated with multiple metabolic alterations in insulin sensitive tissues. In an UPLC-qTOF-mass spectrometry-driven non-targeted metabonomics approach we investigated plasma as well as spot urine of 51 non-diabetic, overnight fasted individuals aiming to separate subjects with IGT from controls thereby identify pathways affected by the pre-diabetic metabolic state. We could clearly demonstrate that normal glucose tolerant (NGT) and IGT subjects clustered in two distinct groups independent of the investigated metabonome. These findings reflect considerable differences in individual metabolite fingerprints, both in plasma and urine. Pre-diabetes associated alterations in fatty acid-, tryptophan-, uric acid-, bile acid-, and lysophosphatidylcholine-metabolism, as well as the TCA cycle were identified. Of note, individuals with IGT also showed decreased levels of gut flora-associated metabolites namely hippuric acid, methylxanthine, methyluric acid, and 3-hydroxyhippuric acid. The findings of our non-targeted UPLC-qTOF-MS metabonomics analysis in plasma and spot urine of individuals with IGT vs NGT offers novel insights into the metabolic alterations occurring in the long, asymptomatic period preceding the manifestation of T2DM thereby giving prospects for new intervention targets.
Language英语
WOS IDWOS:000279698500004
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142066
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Immat Biotechnol GmbH, D-72076 Tubingen, Germany
3.Univ Tubingen Hosp, Cent Lab, Div Clin Chem & Pathobiochem, D-72076 Tubingen, Germany
4.Univ Tubingen Hosp, Dept Internal Med 4, D-72076 Tubingen, Germany
5.German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Ecol Chem, D-85764 Neuherberg, Germany
Recommended Citation
GB/T 7714
Zhao, Xinjie,Fritsche, Jens,Wang, Jiangshan,et al. Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits[J]. METABOLOMICS,2010,6(3):362-374.
APA Zhao, Xinjie.,Fritsche, Jens.,Wang, Jiangshan.,Chen, Jing.,Rittig, Kilian.,...&Lehmann, Rainer.(2010).Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits.METABOLOMICS,6(3),362-374.
MLA Zhao, Xinjie,et al."Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits".METABOLOMICS 6.3(2010):362-374.
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