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题名: Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits
作者: Zhao, Xinjie1;  Fritsche, Jens2;  Wang, Jiangshan1;  Chen, Jing1;  Rittig, Kilian4;  Schmitt-Kopplin, Philippe5;  Fritsche, Andreas4;  Haering, Hans-Ulrich4;  Schleicher, Erwin D.3;  Xu, Guowang1;  Lehmann, Rainer3
关键词: Metabolomics ;  UPLC-qTOF-MS ;  Diabetes ;  Pre-diabetes ;  Impaired glucose tolerance
刊名: METABOLOMICS
发表日期: 2010-09-01
DOI: 10.1007/s11306-010-0203-1
卷: 6, 期:3, 页:362-374
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
英文摘要: Impaired glucose tolerance (IGT) which precedes overt type 2 diabetes (T2DM) for decades is associated with multiple metabolic alterations in insulin sensitive tissues. In an UPLC-qTOF-mass spectrometry-driven non-targeted metabonomics approach we investigated plasma as well as spot urine of 51 non-diabetic, overnight fasted individuals aiming to separate subjects with IGT from controls thereby identify pathways affected by the pre-diabetic metabolic state. We could clearly demonstrate that normal glucose tolerant (NGT) and IGT subjects clustered in two distinct groups independent of the investigated metabonome. These findings reflect considerable differences in individual metabolite fingerprints, both in plasma and urine. Pre-diabetes associated alterations in fatty acid-, tryptophan-, uric acid-, bile acid-, and lysophosphatidylcholine-metabolism, as well as the TCA cycle were identified. Of note, individuals with IGT also showed decreased levels of gut flora-associated metabolites namely hippuric acid, methylxanthine, methyluric acid, and 3-hydroxyhippuric acid. The findings of our non-targeted UPLC-qTOF-MS metabonomics analysis in plasma and spot urine of individuals with IGT vs NGT offers novel insights into the metabolic alterations occurring in the long, asymptomatic period preceding the manifestation of T2DM thereby giving prospects for new intervention targets.
关键词[WOS]: IMPAIRED GLUCOSE-TOLERANCE ;  DIABETES-MELLITUS PATIENTS ;  FA/FA OBESE RATS ;  INSULIN-RESISTANCE ;  MASS-SPECTROMETRY ;  ENDOTHELIAL-CELLS ;  SYSTEMS BIOLOGY ;  GUT MICROBIOME ;  FATTY LIVER ;  DISEASE
语种: 英语
WOS记录号: WOS:000279698500004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142066
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Immat Biotechnol GmbH, D-72076 Tubingen, Germany
3.Univ Tubingen Hosp, Cent Lab, Div Clin Chem & Pathobiochem, D-72076 Tubingen, Germany
4.Univ Tubingen Hosp, Dept Internal Med 4, D-72076 Tubingen, Germany
5.German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Ecol Chem, D-85764 Neuherberg, Germany

Recommended Citation:
Zhao, Xinjie,Fritsche, Jens,Wang, Jiangshan,et al. Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits[J]. METABOLOMICS,2010,6(3):362-374.
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