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题名: Progress on the Screening and Analysis of Bioactive Compounds in Traditional Chinese Medicines by Biological Fingerprinting Analysis
作者: Yu, Fengjiao1;  Kong, Liang1, 2;  Zou, Hanfa2;  Lei, Xiaoyuan2
关键词: Traditional Chinese medicines (TCMs) ;  biological fingerprinting analysis ;  screening ;  bioactive components/compounds ;  omics
刊名: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
发表日期: 2010-12-01
卷: 13, 期:10, 页:855-868
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Applied ;  Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Pharmacology & Pharmacy
英文摘要: Traditional Chinese medicines (TCMs), a key branch of natural medicines, play an important role in the treatment of diseases because of their reliable clinical performance. Identification of their active compounds constitutes a bottleneck in the development of TCMs. Screening and analysis of active compounds is a challenge in TCM research. This review summarizes recent progress in the development of biological fingerprinting strategies for screening and analyzing bioactive compounds in TCMs using molecular recognition, metabolism and omics tools. The evaluated strategies include the following techniques: microdialysis/centrifugal ultrafiltration-HPLC, biochromatography, metabolic fingerprinting analysis, 2-dimensional biochromatography and omics fingerprinting analysis.
关键词[WOS]: IMMOBILIZED LIPOSOME CHROMATOGRAPHY ;  PERFORMANCE LIQUID-CHROMATOGRAPHY ;  HUMAN SERUM-ALBUMIN ;  IONIZATION MASS-SPECTROMETER ;  LONGDAN-XIEGAN-DECOCTION ;  DRUG DISCOVERY ;  AFFINITY-CHROMATOGRAPHY ;  STATIONARY-PHASE ;  ACTIVE COMPOUNDS ;  MOLECULAR BIOCHROMATOGRAPHY
语种: 英语
WOS记录号: WOS:000284622300005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142091
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Ocean Univ, Key Lab Offshore Marine Environm Res Liaoning Hig, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Yu, Fengjiao,Kong, Liang,Zou, Hanfa,et al. Progress on the Screening and Analysis of Bioactive Compounds in Traditional Chinese Medicines by Biological Fingerprinting Analysis[J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2010,13(10):855-868.
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