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Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood
Zhang, Min1; He, Xiwen1; Chen, Langxing1; Zhang, Yukui1,2
刊名JOURNAL OF MATERIALS CHEMISTRY
2010
DOI10.1039/c0jm01336f
20期:47页:10696-10704
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
类目[WOS]Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Materials Science
关键词[WOS]IRON-OXIDE NANOPARTICLES ; GOLD NANOPARTICLES ; FE3O4-AT-AU NANOPARTICLES ; BIOMEDICAL APPLICATIONS ; SILICA NANOPARTICLES ; PHOTOTHERMAL THERAPY ; SURFACE-CHEMISTRY ; FACILE SYNTHESIS ; FE OXIDE ; SHELL
英文摘要In this study, we report a method to synthesize core-satellite structured Fe3O4/polydopamine/Au composite nanoparticles (NPs). Firstly, the Fe3O4/polydopamine composite NPs with a well-defined core-shell structure are obtained using dopamine self-polymerization to form thin, surface-adherent polydopamine films onto the surface of a Fe3O4 "core". The polydopamine shell could be adjusted by controlling the experimental parameters such as reaction time and the reactant concentrations. Then, numerous "satellites" of gold nanoparticles were assembled on the surface of Fe3O4/polydopamine by reducing Au3+ between the Fe3O4/polydopamine solid and HAuCl4 solution. Next, 11-mercaptoundecanoic acid (11-MUA) forms a self-assembled monolayer of MUA on the surface of the Au NPs and polydopamine layer. Finally, IDA-Cu functionalized Fe3O4/polydopamine/Au composite NPs are obtained by the carboxyl groups of MUA reacting with iminodiacetic acid (IDA), charged with Cu2+. The IDA-Cu groups, acting as an "anchor", are attached on the gold and the polydopamine surface is designed for capturing target molecules. The morphology, structure and composition of the nanocomposites are characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectrometry (XPS). The resulting Fe3O4/polydopamine/Au composite NPs show not only a strong magnetic response to an externally applied magnetic field, but are also highly specific to protein bovine hemoglobin (BHb), and removal of abundant protein BHb in the bovine blood as well. This opens a novel route for future application in removing abundant protein in proteomic analysis.
语种英语
WOS记录号WOS:000284542600020
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142190
专题中国科学院大连化学物理研究所
作者单位1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
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GB/T 7714
Zhang, Min,He, Xiwen,Chen, Langxing,et al. Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood[J]. JOURNAL OF MATERIALS CHEMISTRY,2010,20(47):10696-10704.
APA Zhang, Min,He, Xiwen,Chen, Langxing,&Zhang, Yukui.(2010).Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood.JOURNAL OF MATERIALS CHEMISTRY,20(47),10696-10704.
MLA Zhang, Min,et al."Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood".JOURNAL OF MATERIALS CHEMISTRY 20.47(2010):10696-10704.
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