DICP OpenIR
Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood
Zhang, Min1; He, Xiwen1; Chen, Langxing1; Zhang, Yukui1,2
Source PublicationJOURNAL OF MATERIALS CHEMISTRY
2010
DOI10.1039/c0jm01336f
Volume20Issue:47Pages:10696-10704
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary
WOS Research AreaChemistry ; Materials Science
WOS KeywordIRON-OXIDE NANOPARTICLES ; GOLD NANOPARTICLES ; FE3O4-AT-AU NANOPARTICLES ; BIOMEDICAL APPLICATIONS ; SILICA NANOPARTICLES ; PHOTOTHERMAL THERAPY ; SURFACE-CHEMISTRY ; FACILE SYNTHESIS ; FE OXIDE ; SHELL
AbstractIn this study, we report a method to synthesize core-satellite structured Fe3O4/polydopamine/Au composite nanoparticles (NPs). Firstly, the Fe3O4/polydopamine composite NPs with a well-defined core-shell structure are obtained using dopamine self-polymerization to form thin, surface-adherent polydopamine films onto the surface of a Fe3O4 "core". The polydopamine shell could be adjusted by controlling the experimental parameters such as reaction time and the reactant concentrations. Then, numerous "satellites" of gold nanoparticles were assembled on the surface of Fe3O4/polydopamine by reducing Au3+ between the Fe3O4/polydopamine solid and HAuCl4 solution. Next, 11-mercaptoundecanoic acid (11-MUA) forms a self-assembled monolayer of MUA on the surface of the Au NPs and polydopamine layer. Finally, IDA-Cu functionalized Fe3O4/polydopamine/Au composite NPs are obtained by the carboxyl groups of MUA reacting with iminodiacetic acid (IDA), charged with Cu2+. The IDA-Cu groups, acting as an "anchor", are attached on the gold and the polydopamine surface is designed for capturing target molecules. The morphology, structure and composition of the nanocomposites are characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectrometry (XPS). The resulting Fe3O4/polydopamine/Au composite NPs show not only a strong magnetic response to an externally applied magnetic field, but are also highly specific to protein bovine hemoglobin (BHb), and removal of abundant protein BHb in the bovine blood as well. This opens a novel route for future application in removing abundant protein in proteomic analysis.
Language英语
WOS IDWOS:000284542600020
Citation statistics
Cited Times:95[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142190
Collection中国科学院大连化学物理研究所
Affiliation1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Min,He, Xiwen,Chen, Langxing,et al. Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood[J]. JOURNAL OF MATERIALS CHEMISTRY,2010,20(47):10696-10704.
APA Zhang, Min,He, Xiwen,Chen, Langxing,&Zhang, Yukui.(2010).Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood.JOURNAL OF MATERIALS CHEMISTRY,20(47),10696-10704.
MLA Zhang, Min,et al."Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood".JOURNAL OF MATERIALS CHEMISTRY 20.47(2010):10696-10704.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Min]'s Articles
[He, Xiwen]'s Articles
[Chen, Langxing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Min]'s Articles
[He, Xiwen]'s Articles
[Chen, Langxing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Min]'s Articles
[He, Xiwen]'s Articles
[Chen, Langxing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.