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题名: Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood
作者: Zhang, Min1;  He, Xiwen1;  Chen, Langxing1;  Zhang, Yukui1, 2
刊名: JOURNAL OF MATERIALS CHEMISTRY
发表日期: 2010
DOI: 10.1039/c0jm01336f
卷: 20, 期:47, 页:10696-10704
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Physical ;  Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ;  Materials Science
英文摘要: In this study, we report a method to synthesize core-satellite structured Fe3O4/polydopamine/Au composite nanoparticles (NPs). Firstly, the Fe3O4/polydopamine composite NPs with a well-defined core-shell structure are obtained using dopamine self-polymerization to form thin, surface-adherent polydopamine films onto the surface of a Fe3O4 "core". The polydopamine shell could be adjusted by controlling the experimental parameters such as reaction time and the reactant concentrations. Then, numerous "satellites" of gold nanoparticles were assembled on the surface of Fe3O4/polydopamine by reducing Au3+ between the Fe3O4/polydopamine solid and HAuCl4 solution. Next, 11-mercaptoundecanoic acid (11-MUA) forms a self-assembled monolayer of MUA on the surface of the Au NPs and polydopamine layer. Finally, IDA-Cu functionalized Fe3O4/polydopamine/Au composite NPs are obtained by the carboxyl groups of MUA reacting with iminodiacetic acid (IDA), charged with Cu2+. The IDA-Cu groups, acting as an "anchor", are attached on the gold and the polydopamine surface is designed for capturing target molecules. The morphology, structure and composition of the nanocomposites are characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectrometry (XPS). The resulting Fe3O4/polydopamine/Au composite NPs show not only a strong magnetic response to an externally applied magnetic field, but are also highly specific to protein bovine hemoglobin (BHb), and removal of abundant protein BHb in the bovine blood as well. This opens a novel route for future application in removing abundant protein in proteomic analysis.
关键词[WOS]: IRON-OXIDE NANOPARTICLES ;  GOLD NANOPARTICLES ;  FE3O4-AT-AU NANOPARTICLES ;  BIOMEDICAL APPLICATIONS ;  SILICA NANOPARTICLES ;  PHOTOTHERMAL THERAPY ;  SURFACE-CHEMISTRY ;  FACILE SYNTHESIS ;  FE OXIDE ;  SHELL
语种: 英语
WOS记录号: WOS:000284542600020
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142190
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Zhang, Min,He, Xiwen,Chen, Langxing,et al. Preparation of IDA-Cu functionalized core-satellite Fe3O4/polydopamine/Au magnetic nanocomposites and their application for depletion of abundant protein in bovine blood[J]. JOURNAL OF MATERIALS CHEMISTRY,2010,20(47):10696-10704.
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