中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles
作者: Yu, Zhi-Xiang1;  Wang, Yi1;  Wang, Yuanyuan1
关键词: cycloaddition ;  eight-membered carbocycles ;  total synthesis ;  transition metals
刊名: CHEMISTRY-AN ASIAN JOURNAL
发表日期: 2010
DOI: 10.1002/asia.200900712
卷: 5, 期:5, 页:1072-1088
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Eight-membered carbocycles are found in a wide variety of natural products that exhibit a broad range of biological and medicinal activities (cf. the most potent anticancer drug, taxol). However, the synthesis of eight-membered carbocycles is quite challenging as traditional approaches are met with entropic and enthalpic penalties in the ring-forming transition states. These negative effects can be totally or partially avoided with the implementation of transition-metal-catalyzed/mediated cycloadditions. In this Focus Review, examples of elegant and efficient metal-catalyzed and some metal-mediated cycloadditions (including Ni- catalyzed [4+4] and Rh-catalyzed [4+2+2] and [5+2+1] reactions) are presented to illustrate this. Application of these cycloaddition reactions in total synthesis is also presented to show the significance of these reactions in addressing challenges in natural product synthesis.
关键词[WOS]: HIGHER-ORDER CYCLOADDITION ;  RING-CLOSING METATHESIS ;  RH(I)-CATALYZED (5+2)+1 CYCLOADDITION ;  4+2 CYCLOISOMERIZATION REACTIONS ;  BIFUNCTIONAL CHAIN MOLECULES ;  BETA-CARBON ELIMINATION ;  MEDIUM-SIZED RINGS ;  HOMO DIELS-ALDER ;  6-PI+2-PI CYCLOADDITION ;  CONJUGATED DIENES
语种: 英语
WOS记录号: WOS:000277724800008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142206
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China

Recommended Citation:
Yu, Zhi-Xiang,Wang, Yi,Wang, Yuanyuan. Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Eight-Membered Carbocycles[J]. CHEMISTRY-AN ASIAN JOURNAL,2010,5(5):1072-1088.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Yu, Zhi-Xiang]'s Articles
 [Wang, Yi]'s Articles
 [Wang, Yuanyuan]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Yu, Zhi-Xiang]‘s Articles
 [Wang, Yi]‘s Articles
 [Wang, Yuanyuan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace