DICP OpenIR
Chitosan-g-MPEG-Modified Alginate/Chitosan Hydrogel Microcapsules: A Quantitative Study of the Effect of Polymer Architecture on the Resistance to Protein Adsorption
Zheng, Jia N.2,3; Xie, Hong G.2; Yu, Wei T.2; Liu, Xiu D.1; Xie, Wei Y.2; Zhu, Jing2; Ma, Xiao J.2
Source PublicationLANGMUIR
2010-11-16
DOI10.1021/la1030203
Volume26Issue:22Pages:17156-17164
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS Research AreaChemistry ; Materials Science
WOS KeywordCELL ENCAPSULATION ; SURFACE ; TECHNOLOGY ; COPOLYMERS ; CHARGE ; GEL
AbstractThe chemical modification of the aginate/chitosan/aginate (ACA) hydrogel microcapsule with methoxy poly(ethylene glycol) (MPEG) was investigated to reduce nonspecific protein adsorption and improve biocompatibility in vivo. The graft copolymer chitosan-g-M PEG (CS-g-M PEG) was synthesized. and then alginate/chitosan/alginate/CS-g-MPEG (ACAC(PEG)) multilayer hydrogel microcapsules were fabricated by the layer-by-layer (LBL) polyelectrolyte self-assembly method. A quantitative study of the modification was carried out by the gel permeation chromatography (G PC) technique, and protein adsorption on the modified microcapsules was also investigated. The results showed that the apparent graft density of the M PEG side chain on the microcapsules decreased with increases in the degree of substitution (DS) and the M PEG chain length. During the binding process, the apparent graft density of CS-g-M PEG showed rapid growth plateau rapid growth behavior, CS-g-M PEG was not only bound to the surface but also penetrated a certain depth into the microcapsule membranes. The copolymers that penetrated the microcapsules made a smaller contribution to protein repulsion than did the copolymers on the surfaces of the microcapsules. The protein repulsion ability decreased with the increase in DS from 7 to 29% with the same chain length of M PEG 2K. CS-g-MPEG with MPEG 2K was more effective at protein repulsion than CS-g-M PEG with M PEG 550, having a similar DS below 20%. In this study, the microcapsules modified with CS-g-MPEG2K-DS7% had the lowest IgG adsorption of 3.0 +/- 0.6 mu g/cm(2), a reduction of 61% compared to that on the chitosan surface.
Language英语
WOS IDWOS:000283837800071
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142211
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100019, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Jia N.,Xie, Hong G.,Yu, Wei T.,et al. Chitosan-g-MPEG-Modified Alginate/Chitosan Hydrogel Microcapsules: A Quantitative Study of the Effect of Polymer Architecture on the Resistance to Protein Adsorption[J]. LANGMUIR,2010,26(22):17156-17164.
APA Zheng, Jia N..,Xie, Hong G..,Yu, Wei T..,Liu, Xiu D..,Xie, Wei Y..,...&Ma, Xiao J..(2010).Chitosan-g-MPEG-Modified Alginate/Chitosan Hydrogel Microcapsules: A Quantitative Study of the Effect of Polymer Architecture on the Resistance to Protein Adsorption.LANGMUIR,26(22),17156-17164.
MLA Zheng, Jia N.,et al."Chitosan-g-MPEG-Modified Alginate/Chitosan Hydrogel Microcapsules: A Quantitative Study of the Effect of Polymer Architecture on the Resistance to Protein Adsorption".LANGMUIR 26.22(2010):17156-17164.
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