中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Chitosan-g-MPEG-Modified Alginate/Chitosan Hydrogel Microcapsules: A Quantitative Study of the Effect of Polymer Architecture on the Resistance to Protein Adsorption
作者: Zheng, Jia N.2, 3;  Xie, Hong G.2;  Yu, Wei T.2;  Liu, Xiu D.1;  Xie, Wei Y.2;  Zhu, Jing2;  Ma, Xiao J.2
刊名: LANGMUIR
发表日期: 2010-11-16
DOI: 10.1021/la1030203
卷: 26, 期:22, 页:17156-17164
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Multidisciplinary ;  Chemistry, Physical ;  Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ;  Materials Science
英文摘要: The chemical modification of the aginate/chitosan/aginate (ACA) hydrogel microcapsule with methoxy poly(ethylene glycol) (MPEG) was investigated to reduce nonspecific protein adsorption and improve biocompatibility in vivo. The graft copolymer chitosan-g-M PEG (CS-g-M PEG) was synthesized. and then alginate/chitosan/alginate/CS-g-MPEG (ACAC(PEG)) multilayer hydrogel microcapsules were fabricated by the layer-by-layer (LBL) polyelectrolyte self-assembly method. A quantitative study of the modification was carried out by the gel permeation chromatography (G PC) technique, and protein adsorption on the modified microcapsules was also investigated. The results showed that the apparent graft density of the M PEG side chain on the microcapsules decreased with increases in the degree of substitution (DS) and the M PEG chain length. During the binding process, the apparent graft density of CS-g-M PEG showed rapid growth plateau rapid growth behavior, CS-g-M PEG was not only bound to the surface but also penetrated a certain depth into the microcapsule membranes. The copolymers that penetrated the microcapsules made a smaller contribution to protein repulsion than did the copolymers on the surfaces of the microcapsules. The protein repulsion ability decreased with the increase in DS from 7 to 29% with the same chain length of M PEG 2K. CS-g-MPEG with MPEG 2K was more effective at protein repulsion than CS-g-M PEG with M PEG 550, having a similar DS below 20%. In this study, the microcapsules modified with CS-g-MPEG2K-DS7% had the lowest IgG adsorption of 3.0 +/- 0.6 mu g/cm(2), a reduction of 61% compared to that on the chitosan surface.
关键词[WOS]: CELL ENCAPSULATION ;  SURFACE ;  TECHNOLOGY ;  COPOLYMERS ;  CHARGE ;  GEL
语种: 英语
WOS记录号: WOS:000283837800071
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142211
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100019, Peoples R China

Recommended Citation:
Zheng, Jia N.,Xie, Hong G.,Yu, Wei T.,et al. Chitosan-g-MPEG-Modified Alginate/Chitosan Hydrogel Microcapsules: A Quantitative Study of the Effect of Polymer Architecture on the Resistance to Protein Adsorption[J]. LANGMUIR,2010,26(22):17156-17164.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Zheng, Jia N.]'s Articles
 [Xie, Hong G.]'s Articles
 [Yu, Wei T.]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Zheng, Jia N.]‘s Articles
 [Xie, Hong G.]‘s Articles
 [Yu, Wei T.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace