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题名: MiCroKit 3.0: an integrated database of midbody, centrosome and kinetochore
作者: Ren, Jian1, 2;  Liu, Zexian1, 2;  Gao, Xinjiao1, 2;  Jin, Changjiang1, 2;  Ye, Mingliang3;  Zou, Hanfa3;  Wen, Longping1, 2, 4;  Zhang, Zhaolei5;  Xue, Yu1, 2, 4;  Yao, Xuebiao1, 2
刊名: NUCLEIC ACIDS RESEARCH
发表日期: 2010
DOI: 10.1093/nar/gkp784
卷: 38, 页:D155-D160
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: During cell division/mitosis, a specific subset of proteins is spatially and temporally assembled into protein super complexes in three distinct regions, i.e. centrosome/spindle pole, kinetochore/centromere and midbody/cleavage furrow/phragmoplast/bud neck, and modulates cell division process faithfully. Although many experimental efforts have been carried out to investigate the characteristics of these proteins, no integrated database was available. Here, we present the MiCroKit database (http://microkit.biocuckoo.org) of proteins that localize in midbody, centrosome and/or kinetochore. We collected into the MiCroKit database experimentally verified microkit proteins from the scientific literature that have unambiguous supportive evidence for subcellular localization under fluorescent microscope. The current version of MiCroKit 3.0 provides detailed information for 1489 microkit proteins from seven model organisms, including Saccharomyces cerevisiae, Schizasaccharomyces pombe, Caenorhabditis elegans, Drosophila melanogaster, Xenopus laevis, Mus musculus and Homo sapiens. Moreover, the orthologous information was provided for these microkit proteins, and could be a useful resource for further experimental identification. The online service of MiCroKit database was implemented in PHP+MySQL+JavaScript, while the local packages were developed in JAVA 1.5 (J2SE 5.0).
关键词[WOS]: EXTRA CENTROSOMES ;  CELL-DIVISION ;  CYTOKINESIS ;  SURVIVIN ;  ARCHITECTURE ;  INTERFACE ;  APOPTOSIS ;  ORTHOLOGS ;  PROTEINS
语种: 英语
WOS记录号: WOS:000276399100025
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142212
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
4.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China
5.Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

Recommended Citation:
Ren, Jian,Liu, Zexian,Gao, Xinjiao,et al. MiCroKit 3.0: an integrated database of midbody, centrosome and kinetochore[J]. NUCLEIC ACIDS RESEARCH,2010,38:D155-D160.
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