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Characterization of steroidal saponins in crude extracts from Dioscorea zingiberensis C. H. Wright by ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry
Zhu, Jingbo1; Guo, Xiujie1; Fu, Shaoping1; Zhang, Xiuli2; Liang, Xinmiao2
KeywordSteroidal Saponin Dioscorea Zingiberensis c h Wright Uplc Q-tof-ms/ms Structural Elucidation
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2010-11-02
DOI10.1016/j.jpba.2010.05.019
Volume53Issue:3Pages:462-474
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordELECTROSPRAY-IONIZATION ; STRUCTURAL-CHARACTERIZATION ; ANTINEOPLASTIC AGENTS ; RAPID IDENTIFICATION ; RHIZOMES ; GLYCOSIDES ; HYPOGLAUCA ; MS/MS
AbstractSteroidal saponins are the major bioactive constituents of Dioscorea zingiberensis C H Wright (D zingiberensis) In this work, ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS/MS) was applied to the separation and characterization of steroidal saponins in crude extracts from D zingiberensis. The results showed that fragment ions from glycosidic and cross-ring cleavages gave a wealth of structural information related to aglycone skeletons, sugar types and the sequence of sugar units. According to the summarized fragmentation patterns, identification of steroidal saponins from D zingiberensis could be fulfilled, even when reference standards were unavailable As a result, a total of thirty-one saponins with five aglycone skeletons, including fourteen new trace saponins, were identified or tentatively elucidated in crude extracts from D zingiberensis based on their retention times, the mass spectrometric fragmentation patterns, and MS and MS/MS data (c) 2010 Elsevier B V All rights reserved
Language英语
WOS IDWOS:000280435800033
Citation statistics
Cited Times:48[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142222
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Polytech Univ, Inst Chem & Applicat Plant Resource, Sch Biol & Food Engn, Dalian 116034, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Jingbo,Guo, Xiujie,Fu, Shaoping,et al. Characterization of steroidal saponins in crude extracts from Dioscorea zingiberensis C. H. Wright by ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2010,53(3):462-474.
APA Zhu, Jingbo,Guo, Xiujie,Fu, Shaoping,Zhang, Xiuli,&Liang, Xinmiao.(2010).Characterization of steroidal saponins in crude extracts from Dioscorea zingiberensis C. H. Wright by ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,53(3),462-474.
MLA Zhu, Jingbo,et al."Characterization of steroidal saponins in crude extracts from Dioscorea zingiberensis C. H. Wright by ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 53.3(2010):462-474.
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