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题名: Production of two intermediate taxoids, 2-hydroxy-5 alpha, 10 beta-diacetoxytaxadiene and 2-hydroxy-5 alpha, 10 beta, 14 beta-triacetoxytaxadiene, from Taxus chinensis cell culture
作者: Gao, Ming-Bo1, 2, 3;  Zhang, Wei1, 4;  Yue, Xiang-Guo1, 2;  Xiao, Hong-Bin5
关键词: Taxus chinensis ;  taxuyunnanine C ;  methyl jasmonate ;  2,3-dihydroxypropyl jasmonate ;  in situ absorption ;  2-hydroxy-5 alpha, 10 beta-diacetoxytaxadiene ;  2-hydroxy-5 alpha, 10 beta, 14 beta-triacetoxytaxadiene
刊名: AFRICAN JOURNAL OF BIOTECHNOLOGY
发表日期: 2010-12-06
卷: 9, 期:49, 页:8486-8491
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
英文摘要: The production of taxuyunnanine C (Tc) (2 alpha, 5 alpha, 10 beta, 14 beta-tetraacetoxytaxa-4(20), 11(12)-diene) was significantly enhanced when Taxus chinensis cell cultures were treated with methyl jasmonate (MJA) or 2,3-dihydroxypropyl jasmonate (DHPJA), a newly synthesized jasmonate analog, in combination with in situ absorption. Along with the production of Tc, two intermediate taxoids were produced and purified. On the basis of liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectral data, the chemical structures of the two intermediate taxoids were found to be 2-hydroxy-5 alpha, 10 beta-diacetoxytaxadiene and 2-hydroxy-5 alpha, 10 beta, 14 beta-triacetoxytaxadiene. This is the first study to report the production of these two taxoids using plant cell culture.
关键词[WOS]: 1ST OXYGENATION STEP ;  SUSPENSION-CULTURES ;  GERANYLGERANYL DIPHOSPHATE ;  PACLITAXEL PRODUCTION ;  TAXANE DITERPENOIDS ;  TAXADIENE SYNTHASE ;  METHYL JASMONATE ;  COMMITTED STEP ;  BIOSYNTHESIS ;  EXPRESSION
语种: 英语
WOS记录号: WOS:000285650000033
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142256
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100089, Peoples R China
3.Dalian Nationalities Univ, SEAC ME, Key Lab Biochem Engn, Dalian 116600, Peoples R China
4.Flinders Univ S Australia, Sch Med, Dept Med Biotechnol, Mol Bioproc & Bioprod Lab, Adelaide, SA 5042, Australia
5.Chinese Acad Sci, Dalian Inst Chem Phys, Med Chem Grp, Dalian 116023, Peoples R China

Recommended Citation:
Gao, Ming-Bo,Zhang, Wei,Yue, Xiang-Guo,et al. Production of two intermediate taxoids, 2-hydroxy-5 alpha, 10 beta-diacetoxytaxadiene and 2-hydroxy-5 alpha, 10 beta, 14 beta-triacetoxytaxadiene, from Taxus chinensis cell culture[J]. AFRICAN JOURNAL OF BIOTECHNOLOGY,2010,9(49):8486-8491.
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