中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells
作者: Liu, Xing-yu2, 3;  Yang, Zhi-hua1;  Pan, Xiu-jie1;  Zhu, Mao-xiang1;  Xie, Jian-ping3
关键词: Crotonaldehyde ;  Oxidative stress ;  Apoptosis ;  Caspase
刊名: TOXICOLOGY LETTERS
发表日期: 2010-05-19
DOI: 10.1016/j.toxlet.2010.02.004
卷: 195, 期:1, 页:90-98
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
英文摘要: Crotonaldehyde is a widespread environmental pollutant and lipid peroxidation product. Crotonaldehyde is a risk factor for many diseases (e.g., chronic pulmonary inflammation). However, its toxicity and its mechanism of action have not been thoroughly investigated. The purpose of this study is to investigate crotonaldehyde-induced oxidative stress and mechanism of cell death in BEAS-2B cells. Crotonaldehyde caused decreases of intracellular reduced glutathione levels and increases of reactive oxygen species in a dose-dependent manner. Crotonaldehyde induced cell death by apoptosis, and gradually transitioned to necrosis at high dose of crotonaldehyde, as demonstrated by Annexin V-FITC/PI staining and cell morphology analysis. Crotonaldehyde-induced ATP decline observed in the study might partially account for the switch from apoptosis to necrosis. Mitochondria membrane potential, cytochrome c release, caspase-9, and caspase-3/7 activity were investigated, and the results suggest that crotonaldehyde-induced apoptosis was activated in a caspase-dependent way. Collectively, these results demonstrate crotonaldehyde induces cell oxidative stress and caspase-dependent apoptosis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词[WOS]: MITOCHONDRIAL PERMEABILITY TRANSITION ;  ACROLEIN-INDUCED APOPTOSIS ;  CIGARETTE-SMOKE ;  CYTOCHROME-C ;  ALPHA,BETA-UNSATURATED ALDEHYDES ;  N-ACETYLCYSTEINE ;  GLUTATHIONE ;  DEATH ;  INHIBITION ;  GENERATION
语种: 英语
WOS记录号: WOS:000278451100013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142263
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
3.Zhengzhou Tobacco Res Inst CNTC, Zhengzhou 450001, Henan, Peoples R China

Recommended Citation:
Liu, Xing-yu,Yang, Zhi-hua,Pan, Xiu-jie,et al. Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells[J]. TOXICOLOGY LETTERS,2010,195(1):90-98.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Liu, Xing-yu]'s Articles
 [Yang, Zhi-hua]'s Articles
 [Pan, Xiu-jie]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Liu, Xing-yu]‘s Articles
 [Yang, Zhi-hua]‘s Articles
 [Pan, Xiu-jie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace