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Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells
Liu, Xing-yu2,3; Yang, Zhi-hua1; Pan, Xiu-jie1; Zhu, Mao-xiang1; Xie, Jian-ping3
关键词Crotonaldehyde Oxidative Stress Apoptosis Caspase
刊名TOXICOLOGY LETTERS
2010-05-19
DOI10.1016/j.toxlet.2010.02.004
195期:1页:90-98
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]MITOCHONDRIAL PERMEABILITY TRANSITION ; ACROLEIN-INDUCED APOPTOSIS ; CIGARETTE-SMOKE ; CYTOCHROME-C ; ALPHA,BETA-UNSATURATED ALDEHYDES ; N-ACETYLCYSTEINE ; GLUTATHIONE ; DEATH ; INHIBITION ; GENERATION
英文摘要Crotonaldehyde is a widespread environmental pollutant and lipid peroxidation product. Crotonaldehyde is a risk factor for many diseases (e.g., chronic pulmonary inflammation). However, its toxicity and its mechanism of action have not been thoroughly investigated. The purpose of this study is to investigate crotonaldehyde-induced oxidative stress and mechanism of cell death in BEAS-2B cells. Crotonaldehyde caused decreases of intracellular reduced glutathione levels and increases of reactive oxygen species in a dose-dependent manner. Crotonaldehyde induced cell death by apoptosis, and gradually transitioned to necrosis at high dose of crotonaldehyde, as demonstrated by Annexin V-FITC/PI staining and cell morphology analysis. Crotonaldehyde-induced ATP decline observed in the study might partially account for the switch from apoptosis to necrosis. Mitochondria membrane potential, cytochrome c release, caspase-9, and caspase-3/7 activity were investigated, and the results suggest that crotonaldehyde-induced apoptosis was activated in a caspase-dependent way. Collectively, these results demonstrate crotonaldehyde induces cell oxidative stress and caspase-dependent apoptosis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
语种英语
WOS记录号WOS:000278451100013
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142263
专题中国科学院大连化学物理研究所
作者单位1.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
3.Zhengzhou Tobacco Res Inst CNTC, Zhengzhou 450001, Henan, Peoples R China
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GB/T 7714
Liu, Xing-yu,Yang, Zhi-hua,Pan, Xiu-jie,et al. Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells[J]. TOXICOLOGY LETTERS,2010,195(1):90-98.
APA Liu, Xing-yu,Yang, Zhi-hua,Pan, Xiu-jie,Zhu, Mao-xiang,&Xie, Jian-ping.(2010).Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells.TOXICOLOGY LETTERS,195(1),90-98.
MLA Liu, Xing-yu,et al."Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells".TOXICOLOGY LETTERS 195.1(2010):90-98.
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