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Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells
Liu, Xing-yu2,3; Yang, Zhi-hua1; Pan, Xiu-jie1; Zhu, Mao-xiang1; Xie, Jian-ping3
KeywordCrotonaldehyde Oxidative Stress Apoptosis Caspase
Source PublicationTOXICOLOGY LETTERS
2010-05-19
DOI10.1016/j.toxlet.2010.02.004
Volume195Issue:1Pages:90-98
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectToxicology
WOS Research AreaToxicology
WOS KeywordMITOCHONDRIAL PERMEABILITY TRANSITION ; ACROLEIN-INDUCED APOPTOSIS ; CIGARETTE-SMOKE ; CYTOCHROME-C ; ALPHA,BETA-UNSATURATED ALDEHYDES ; N-ACETYLCYSTEINE ; GLUTATHIONE ; DEATH ; INHIBITION ; GENERATION
AbstractCrotonaldehyde is a widespread environmental pollutant and lipid peroxidation product. Crotonaldehyde is a risk factor for many diseases (e.g., chronic pulmonary inflammation). However, its toxicity and its mechanism of action have not been thoroughly investigated. The purpose of this study is to investigate crotonaldehyde-induced oxidative stress and mechanism of cell death in BEAS-2B cells. Crotonaldehyde caused decreases of intracellular reduced glutathione levels and increases of reactive oxygen species in a dose-dependent manner. Crotonaldehyde induced cell death by apoptosis, and gradually transitioned to necrosis at high dose of crotonaldehyde, as demonstrated by Annexin V-FITC/PI staining and cell morphology analysis. Crotonaldehyde-induced ATP decline observed in the study might partially account for the switch from apoptosis to necrosis. Mitochondria membrane potential, cytochrome c release, caspase-9, and caspase-3/7 activity were investigated, and the results suggest that crotonaldehyde-induced apoptosis was activated in a caspase-dependent way. Collectively, these results demonstrate crotonaldehyde induces cell oxidative stress and caspase-dependent apoptosis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Language英语
WOS IDWOS:000278451100013
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142263
Collection中国科学院大连化学物理研究所
Affiliation1.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
3.Zhengzhou Tobacco Res Inst CNTC, Zhengzhou 450001, Henan, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xing-yu,Yang, Zhi-hua,Pan, Xiu-jie,et al. Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells[J]. TOXICOLOGY LETTERS,2010,195(1):90-98.
APA Liu, Xing-yu,Yang, Zhi-hua,Pan, Xiu-jie,Zhu, Mao-xiang,&Xie, Jian-ping.(2010).Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells.TOXICOLOGY LETTERS,195(1),90-98.
MLA Liu, Xing-yu,et al."Crotonaldehyde induces oxidative stress and caspase-dependent apoptosis in human bronchial epithelial cells".TOXICOLOGY LETTERS 195.1(2010):90-98.
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