DICP OpenIR
Classification and differential metabolite discovery of liver diseases based on plasma metabolic profiling and support vector machines
Lin, Xiaohui2; Zhang, Yang2; Ye, Guozhu1; Li, Xiang1; Yin, Peiyuan1; Ruan, Qiang2; Xu, Guowang1
关键词Analysis Of Variance Gc-ms Liver Diseases Metabonomics Support Vector Machine
刊名JOURNAL OF SEPARATION SCIENCE
2011-11-01
DOI10.1002/jssc.201100408
34期:21页:3029-3036
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]GAS CHROMATOGRAPHY/MASS SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; FLIGHT-MASS-SPECTROMETRY ; HEPATOCELLULAR-CARCINOMA ; FEATURE-SELECTION ; AMINO-ACID ; GENE-EXPRESSION ; MICROARRAY DATA ; HUMAN URINE ; GC-MS
英文摘要Discovery of differential metabolites is the focus of metabonomics study. It has very important applications in pathogenesis and disease classification. The aim of this work is to identify differential metabolites for classifying the patients with hepatocellular carcinoma, cirrhosis and hepatitis based on metabolic profiling data analyzed by gas chromatography-time of flight mass spectrometry. A two-stage feature selection algorithm, F-SVM, combining F-score in analysis of variance and support vector machine (SVM), was applied in discovering discriminative metabolites for three different types of liver diseases. The results show that the accuracy rate of the double cross-validation was 73.68 +/- 2.98%. 22 important differential metabolites selected by F-SVM were identified and related pathophysiological process of liver diseases was set forth. We conclude that F-SVM is quite feasible to be applied in the selection of biologically relevant features in metabonomics.
语种英语
WOS记录号WOS:000297415600014
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142281
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian, Peoples R China
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Lin, Xiaohui,Zhang, Yang,Ye, Guozhu,et al. Classification and differential metabolite discovery of liver diseases based on plasma metabolic profiling and support vector machines[J]. JOURNAL OF SEPARATION SCIENCE,2011,34(21):3029-3036.
APA Lin, Xiaohui.,Zhang, Yang.,Ye, Guozhu.,Li, Xiang.,Yin, Peiyuan.,...&Xu, Guowang.(2011).Classification and differential metabolite discovery of liver diseases based on plasma metabolic profiling and support vector machines.JOURNAL OF SEPARATION SCIENCE,34(21),3029-3036.
MLA Lin, Xiaohui,et al."Classification and differential metabolite discovery of liver diseases based on plasma metabolic profiling and support vector machines".JOURNAL OF SEPARATION SCIENCE 34.21(2011):3029-3036.
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