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Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative
Zhang, Zhenjiang; He, Xiangwei; Yuan, Gu
KeywordG-quadruplex C-myc Pyrene Derivatives Rational Drug Design Transcription Control
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2011-12-01
DOI10.1016/j.ijbiomac.2011.05.024
Volume49Issue:5Pages:1173-1176
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordSMALL-MOLECULE ; IN-VIVO ; TELOMERASE ; GROWTH ; GENE ; PROLIFERATION ; STABILIZATION ; TRANSCRIPTION ; STABILITY ; PORPHYRIN
AbstractIt has been established that the equilibrium between duplex and G-quadruplex of the nuclease hypersensitivity element III1 (NHE III1) in human c-myc promoter is linked with this gene's transcription. Using NMR and ESI-MS, we have found a pyrene derivative, DMAPP, is able to modulate this equilibrium and, thus, might have the potential to regulate this oncogene's transcription. DMAPP has shown as a G-quadruplex binding agent and could induce c-myc G-quadruplex formation out of duplex. These results provide new clue for rational drug design to target transcription control of c-myc. (C) 2011 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000296937200047
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142321
Collection中国科学院大连化学物理研究所
AffiliationPeking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zhenjiang,He, Xiangwei,Yuan, Gu. Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2011,49(5):1173-1176.
APA Zhang, Zhenjiang,He, Xiangwei,&Yuan, Gu.(2011).Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,49(5),1173-1176.
MLA Zhang, Zhenjiang,et al."Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 49.5(2011):1173-1176.
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