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题名: Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative
作者: Zhang, Zhenjiang1;  He, Xiangwei1;  Yuan, Gu1
关键词: G-quadruplex ;  c-myc ;  Pyrene derivatives ;  Rational drug design ;  Transcription control
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
发表日期: 2011-12-01
DOI: 10.1016/j.ijbiomac.2011.05.024
卷: 49, 期:5, 页:1173-1176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: It has been established that the equilibrium between duplex and G-quadruplex of the nuclease hypersensitivity element III1 (NHE III1) in human c-myc promoter is linked with this gene's transcription. Using NMR and ESI-MS, we have found a pyrene derivative, DMAPP, is able to modulate this equilibrium and, thus, might have the potential to regulate this oncogene's transcription. DMAPP has shown as a G-quadruplex binding agent and could induce c-myc G-quadruplex formation out of duplex. These results provide new clue for rational drug design to target transcription control of c-myc. (C) 2011 Elsevier B.V. All rights reserved.
关键词[WOS]: SMALL-MOLECULE ;  IN-VIVO ;  TELOMERASE ;  GROWTH ;  GENE ;  PROLIFERATION ;  STABILIZATION ;  TRANSCRIPTION ;  STABILITY ;  PORPHYRIN
语种: 英语
WOS记录号: WOS:000296937200047
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142321
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Zhenjiang,He, Xiangwei,Yuan, Gu. Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2011,49(5):1173-1176.
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