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Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry
Cui, Xiaojie; Yuan, Gu
关键词G-quadruplex C-myb Gene Esi-ms Dehydrocorydaline Autodock
刊名JOURNAL OF MASS SPECTROMETRY
2011-09-01
DOI10.1002/jms.1959
46期:9页:849-855
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Spectroscopy
关键词[WOS]HIV-1 INTEGRASE INHIBITORS ; DIMERIC G-QUADRUPLEXES ; TRIPLET REPEAT DNA ; BINDING ; DIFFERENTIATION ; EXPRESSION ; COMPLEXES ; LEUKEMIAS ; GENE ; THERAPEUTICS
英文摘要In this study, electrospray ionization mass spectrometry (ESI-MS) is used to study the formation of G-quadruplex by d(GGAGGAGGAGGA) which locates at the promoter region of c-myb gene. In addition, a natural small molecule, dehydrocorydaline from a Chinese herb, is found to have the highest binding affinity with the G-quadruplex in nine natural small molecules studied, and the binding selectivity of this natural molecule toward the c-myb G-quadruplex with respect to corresponding duplex DNA is significantly higher than that of the broad-spectrum G-quadruplex-ligand TMPyP4. The result from ESI-MS indicates that the gas-phase kinetic stability of the G-quadruplex can be enhanced by binding of dehydrocorydaline. To further investigate the binding properties of dehydrocorydaline to the G-quadruplex, Autodock3 is used to calculate the docked sites and docked energies of small molecules binding to the G-quadruplex and the result shows that the docked energy of dehydrocorydaline is the biggest in the nine small molecules used, consistent with the result from ESI-MS. Copyright (C) 2011 John Wiley & Sons, Ltd.
语种英语
WOS记录号WOS:000295723200001
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142324
专题中国科学院大连化学物理研究所
作者单位Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
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Cui, Xiaojie,Yuan, Gu. Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry[J]. JOURNAL OF MASS SPECTROMETRY,2011,46(9):849-855.
APA Cui, Xiaojie,&Yuan, Gu.(2011).Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry.JOURNAL OF MASS SPECTROMETRY,46(9),849-855.
MLA Cui, Xiaojie,et al."Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry".JOURNAL OF MASS SPECTROMETRY 46.9(2011):849-855.
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