DICP OpenIR
Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry
Cui, Xiaojie; Yuan, Gu
KeywordG-quadruplex C-myb Gene Esi-ms Dehydrocorydaline Autodock
Source PublicationJOURNAL OF MASS SPECTROMETRY
2011-09-01
DOI10.1002/jms.1959
Volume46Issue:9Pages:849-855
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical ; Spectroscopy
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Spectroscopy
WOS KeywordHIV-1 INTEGRASE INHIBITORS ; DIMERIC G-QUADRUPLEXES ; TRIPLET REPEAT DNA ; BINDING ; DIFFERENTIATION ; EXPRESSION ; COMPLEXES ; LEUKEMIAS ; GENE ; THERAPEUTICS
AbstractIn this study, electrospray ionization mass spectrometry (ESI-MS) is used to study the formation of G-quadruplex by d(GGAGGAGGAGGA) which locates at the promoter region of c-myb gene. In addition, a natural small molecule, dehydrocorydaline from a Chinese herb, is found to have the highest binding affinity with the G-quadruplex in nine natural small molecules studied, and the binding selectivity of this natural molecule toward the c-myb G-quadruplex with respect to corresponding duplex DNA is significantly higher than that of the broad-spectrum G-quadruplex-ligand TMPyP4. The result from ESI-MS indicates that the gas-phase kinetic stability of the G-quadruplex can be enhanced by binding of dehydrocorydaline. To further investigate the binding properties of dehydrocorydaline to the G-quadruplex, Autodock3 is used to calculate the docked sites and docked energies of small molecules binding to the G-quadruplex and the result shows that the docked energy of dehydrocorydaline is the biggest in the nine small molecules used, consistent with the result from ESI-MS. Copyright (C) 2011 John Wiley & Sons, Ltd.
Language英语
WOS IDWOS:000295723200001
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142324
Collection中国科学院大连化学物理研究所
AffiliationPeking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Cui, Xiaojie,Yuan, Gu. Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry[J]. JOURNAL OF MASS SPECTROMETRY,2011,46(9):849-855.
APA Cui, Xiaojie,&Yuan, Gu.(2011).Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry.JOURNAL OF MASS SPECTROMETRY,46(9),849-855.
MLA Cui, Xiaojie,et al."Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry".JOURNAL OF MASS SPECTROMETRY 46.9(2011):849-855.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cui, Xiaojie]'s Articles
[Yuan, Gu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cui, Xiaojie]'s Articles
[Yuan, Gu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cui, Xiaojie]'s Articles
[Yuan, Gu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.