中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry
作者: Cui, Xiaojie1;  Yuan, Gu1
关键词: G-quadruplex ;  c-myb gene ;  ESI-MS ;  dehydrocorydaline ;  autodock
刊名: JOURNAL OF MASS SPECTROMETRY
发表日期: 2011-09-01
DOI: 10.1002/jms.1959
卷: 46, 期:9, 页:849-855
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences ;  Technology
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical ;  Spectroscopy
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Spectroscopy
英文摘要: In this study, electrospray ionization mass spectrometry (ESI-MS) is used to study the formation of G-quadruplex by d(GGAGGAGGAGGA) which locates at the promoter region of c-myb gene. In addition, a natural small molecule, dehydrocorydaline from a Chinese herb, is found to have the highest binding affinity with the G-quadruplex in nine natural small molecules studied, and the binding selectivity of this natural molecule toward the c-myb G-quadruplex with respect to corresponding duplex DNA is significantly higher than that of the broad-spectrum G-quadruplex-ligand TMPyP4. The result from ESI-MS indicates that the gas-phase kinetic stability of the G-quadruplex can be enhanced by binding of dehydrocorydaline. To further investigate the binding properties of dehydrocorydaline to the G-quadruplex, Autodock3 is used to calculate the docked sites and docked energies of small molecules binding to the G-quadruplex and the result shows that the docked energy of dehydrocorydaline is the biggest in the nine small molecules used, consistent with the result from ESI-MS. Copyright (C) 2011 John Wiley & Sons, Ltd.
关键词[WOS]: HIV-1 INTEGRASE INHIBITORS ;  DIMERIC G-QUADRUPLEXES ;  TRIPLET REPEAT DNA ;  BINDING ;  DIFFERENTIATION ;  EXPRESSION ;  COMPLEXES ;  LEUKEMIAS ;  GENE ;  THERAPEUTICS
语种: 英语
WOS记录号: WOS:000295723200001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142324
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Cui, Xiaojie,Yuan, Gu. Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry[J]. JOURNAL OF MASS SPECTROMETRY,2011,46(9):849-855.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Cui, Xiaojie]'s Articles
 [Yuan, Gu]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Cui, Xiaojie]‘s Articles
 [Yuan, Gu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace