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Study on membrane characteristics of alginate-chitosan microcapsule with cell growth
Yu, Weiting2; Song, Huiyi2; Zheng, Guoshuang2; Liu, Xiudong1; Zhang, Ying2; Ma, Xiaojun2
关键词Alginate-chitosan Microcapsule Membrane Characteristics Microencapsulated Cell Culture Apparent Membrane
刊名JOURNAL OF MEMBRANE SCIENCE
2011-07-15
DOI10.1016/j.memsci.2011.04.053
377期:1-2页:214-220
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Technology ; Physical Sciences
类目[WOS]Engineering, Chemical ; Polymer Science
研究领域[WOS]Engineering ; Polymer Science
关键词[WOS]OLIGOCHITOSAN MICROCAPSULES ; INTESTINAL DELIVERY ; SWELLING BEHAVIOR ; PREPARED CAPSULE ; MOLECULAR-WEIGHT ; IN-VITRO ; RELEASE ; MICROPARTICLES ; ENCAPSULATION ; MICROSPHERES
英文摘要Alginate-chitosan (AC) microcapsule with polyelectrolyte complex (PEC) membrane has been attractive in biotechnological area such as cell immobilization fermentation. The PEC membrane has been known important to control microcapsule performance, but the knowledge was mainly obtained with empty or drug-loaded microcapsules. In this paper, the emphasis was to explore the influence of cell growth on PEC membrane characteristics, that is, to study the membrane characteristics in dynamic process. AC microcapsule entrapping yeast cells (Saccharomyces cerevisiae BY4741) was used as model, and the PEC membrane characteristics including membrane thickness, swelling behavior, permeability, and component were studied during cell culture process. It was found that both the membrane thickness and volume swelling degree of AC microcapsule increased, however, membrane permeability decreased with the growth of entrapped yeast cells. Fluorescence-labeling studies suggested the concentrated alginate layer squeezed by the proliferated cells and macromolecular metabolites layer secreted by proliferated cells contributed to above increment. The former PEC membrane, together with the new layers, constituted the 'apparent membrane', which increased the diffusion resistance of substances. (C) 2011 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000292580000022
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142364
专题中国科学院大连化学物理研究所
作者单位1.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
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GB/T 7714
Yu, Weiting,Song, Huiyi,Zheng, Guoshuang,et al. Study on membrane characteristics of alginate-chitosan microcapsule with cell growth[J]. JOURNAL OF MEMBRANE SCIENCE,2011,377(1-2):214-220.
APA Yu, Weiting,Song, Huiyi,Zheng, Guoshuang,Liu, Xiudong,Zhang, Ying,&Ma, Xiaojun.(2011).Study on membrane characteristics of alginate-chitosan microcapsule with cell growth.JOURNAL OF MEMBRANE SCIENCE,377(1-2),214-220.
MLA Yu, Weiting,et al."Study on membrane characteristics of alginate-chitosan microcapsule with cell growth".JOURNAL OF MEMBRANE SCIENCE 377.1-2(2011):214-220.
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