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题名: Study on membrane characteristics of alginate-chitosan microcapsule with cell growth
作者: Yu, Weiting2;  Song, Huiyi2;  Zheng, Guoshuang2;  Liu, Xiudong1;  Zhang, Ying2;  Ma, Xiaojun2
关键词: Alginate-chitosan microcapsule ;  Membrane characteristics ;  Microencapsulated cell culture ;  Apparent membrane
刊名: JOURNAL OF MEMBRANE SCIENCE
发表日期: 2011-07-15
DOI: 10.1016/j.memsci.2011.04.053
卷: 377, 期:1-2, 页:214-220
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology ;  Physical Sciences
类目[WOS]: Engineering, Chemical ;  Polymer Science
研究领域[WOS]: Engineering ;  Polymer Science
英文摘要: Alginate-chitosan (AC) microcapsule with polyelectrolyte complex (PEC) membrane has been attractive in biotechnological area such as cell immobilization fermentation. The PEC membrane has been known important to control microcapsule performance, but the knowledge was mainly obtained with empty or drug-loaded microcapsules. In this paper, the emphasis was to explore the influence of cell growth on PEC membrane characteristics, that is, to study the membrane characteristics in dynamic process. AC microcapsule entrapping yeast cells (Saccharomyces cerevisiae BY4741) was used as model, and the PEC membrane characteristics including membrane thickness, swelling behavior, permeability, and component were studied during cell culture process. It was found that both the membrane thickness and volume swelling degree of AC microcapsule increased, however, membrane permeability decreased with the growth of entrapped yeast cells. Fluorescence-labeling studies suggested the concentrated alginate layer squeezed by the proliferated cells and macromolecular metabolites layer secreted by proliferated cells contributed to above increment. The former PEC membrane, together with the new layers, constituted the 'apparent membrane', which increased the diffusion resistance of substances. (C) 2011 Elsevier B.V. All rights reserved.
关键词[WOS]: OLIGOCHITOSAN MICROCAPSULES ;  INTESTINAL DELIVERY ;  SWELLING BEHAVIOR ;  PREPARED CAPSULE ;  MOLECULAR-WEIGHT ;  IN-VITRO ;  RELEASE ;  MICROPARTICLES ;  ENCAPSULATION ;  MICROSPHERES
语种: 英语
WOS记录号: WOS:000292580000022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142364
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China

Recommended Citation:
Yu, Weiting,Song, Huiyi,Zheng, Guoshuang,et al. Study on membrane characteristics of alginate-chitosan microcapsule with cell growth[J]. JOURNAL OF MEMBRANE SCIENCE,2011,377(1-2):214-220.
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