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题名: The impact of MIG1 and/or MIG2 disruption on aerobic metabolism of succinate dehydrogenase negative Saccharomyces cerevisiae
作者: Cao, Hailong1, 2;  Yue, Min1, 2;  Li, Shuguang1;  Bai, Xuefang1;  Zhao, Xiaoming1;  Du, Yuguang1
关键词: Saccharomyces cerevisiae ;  Succinate dehydrogenase ;  MIG1 ;  MIG2 ;  Aerobic metabolism ;  Glucose repression
刊名: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
发表日期: 2011-02-01
DOI: 10.1007/s00253-010-2894-7
卷: 89, 期:3, 页:733-738
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
英文摘要: The zinc finger proteins Mig1 and Mig2 play important roles in glucose repression of Saccharomyces cerevisiae. To investigate whether the alleviation of glucose effect would result in an increase in aerobic succinate production, MIG1 and/or MIG2 were disrupted in a succinate dehydrogenase (SDH)-negative S. cerevisiae strain. Moreover, their impacts on physiology of the SDH-negative S. cerevisiae strain were studied under fully aerobic conditions when glucose was the sole carbon source. Our results showed that the succinate production for the SDH-negative S. cerevisiae was very low even under fully aerobic conditions. Furthermore, deletion of MIG1 and/or MIG2 did not result in an increase in succinate production in the SDH-negative S. cerevisiae strain. However, the synthesis of acetate was significantly affected by MIG1 deletion or in combination with MIG2 deletion. The acetate production for the mig1/mig2 double mutant BS2M was reduced by 69.72% compared to the parent strain B2S. In addition, the amount of ethanol produced by BS2M was slightly decreased. With the mig2 mutant BSM2, the concentrations of pyruvate and glycerol were increased by 26.23% and 15.28%, respectively, compared to the parent strain B2S.
关键词[WOS]: GLUCOSE REPRESSION ;  YEAST ;  ACID ;  FERMENTATION ;  PHYSIOLOGY ;  PATHWAYS ;  STRAIN
语种: 英语
WOS记录号: WOS:000286429400026
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142369
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Cao, Hailong,Yue, Min,Li, Shuguang,et al. The impact of MIG1 and/or MIG2 disruption on aerobic metabolism of succinate dehydrogenase negative Saccharomyces cerevisiae[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2011,89(3):733-738.
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