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Dehydration triggered asymmetric hydrogenation of 3-(alpha-hydroxyalkyl)indoles
Wang, Duo-Sheng1; Tang, Jie2; Zhou, Yong-Gui1; Chen, Mu-Wang1; Yu, Chang-Bin1; Duan, Ying1; Jiang, Guo-Fang2
Source PublicationCHEMICAL SCIENCE
2011
DOI10.1039/c0sc00614a
Volume2Issue:4Pages:803-806
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordPD-CATALYZED HYDROGENATION ; ORGANOCATALYTIC TRANSFER HYDROGENATION ; HIGHLY ENANTIOSELECTIVE SYNTHESIS ; CHIRAL PALLADIUM CATALYSTS ; BRONSTED ACID CATALYSIS ; FRIEDEL-CRAFTS REACTION ; HETEROAROMATIC-COMPOUNDS ; ARYLSULFONYL INDOLES ; 3-(1-ARYLSULFONYLALKYL) INDOLES ; HANTZSCH ESTERS
AbstractHighly enantioselective hydrogenation of 3-(alpha-hydroxyalkyl)indoles promoted by a Bronsted acid for dehydration to form a vinylogous iminium intermediate in situ was developed with Pd(OCOCF3)(2)/(R)-H8-BINAP as catalyst with up to 97% ee. This methodology provides an efficient and rapid access to chiral 2,3-disubstituted indolines.
Language英语
WOS IDWOS:000288387600034
Citation statistics
Cited Times:118[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142370
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Duo-Sheng,Tang, Jie,Zhou, Yong-Gui,et al. Dehydration triggered asymmetric hydrogenation of 3-(alpha-hydroxyalkyl)indoles[J]. CHEMICAL SCIENCE,2011,2(4):803-806.
APA Wang, Duo-Sheng.,Tang, Jie.,Zhou, Yong-Gui.,Chen, Mu-Wang.,Yu, Chang-Bin.,...&Jiang, Guo-Fang.(2011).Dehydration triggered asymmetric hydrogenation of 3-(alpha-hydroxyalkyl)indoles.CHEMICAL SCIENCE,2(4),803-806.
MLA Wang, Duo-Sheng,et al."Dehydration triggered asymmetric hydrogenation of 3-(alpha-hydroxyalkyl)indoles".CHEMICAL SCIENCE 2.4(2011):803-806.
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