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MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION
Yuan, Gu1; Zhang, Qiang1; Zhou, Jiang1; Li, Huihui1,2
关键词Mass Spectrometry G-quadruplex Dna Formation Recognition Conversion
刊名MASS SPECTROMETRY REVIEWS
2011-11-01
DOI10.1002/mas.20315
30期:6页:1121-1142
收录类别SCI
文章类型Review
WOS标题词Science & Technology ; Technology
类目[WOS]Spectroscopy
研究领域[WOS]Spectroscopy
关键词[WOS]HUMAN TELOMERIC DNA ; END-LINKED OLIGONUCLEOTIDES ; INTRAMOLECULAR G-QUADRUPLEX ; HIV-1 INTEGRASE INHIBITORS ; THROMBIN-BINDING APTAMER ; DIMERIC G-QUADRUPLEXES ; GAS-PHASE ; PROMOTER REGION ; C-MYC ; GUANINE-QUADRUPLEXES
英文摘要G-quadruplexes are special secondary structures formed from G-rich sequences of DNA, and have proven to play important roles in a number of biological systems, including the regulation of gene transcription and translation. The highly distinctive nature of G-quadruplex structures and their functions suggest that G-quadruplexes can act as novel targets for drug development. As a highly sensitive analytical tool, mass spectrometry has been widely used for the analysis of G-quadruplex structures. Electrospray-ionization mass spectrometry, in particular, has found captivating applications to probe interactions between small molecules and G-quadruplex DNA. In this review, we will discuss: (1) mass spectrometry probing of the formation, binding affinity, and stoichiometry between G-quadruplexes and small molecules; (2) stabilization and collision-dissociation behavior of G-quadruplex DNA; (3) the exploration of the equilibrium transfer between a G-quadruplex and duplex DNA; and (4) the ESI-MS analysis of the conversion of intramolecular and intermolecular G-quadruplexes. Finally, we will also introduce the application of new techniques in the analysis of G-quadruplex conformation, such as ion-mobility and infrared multiphoton-dissociation mass spectrometry. We believe that, with the new technical developments, mass spectrometry will play an unparalleled role in the analysis of the G-quadruplex structures. (C) 2011 Wiley Periodicals, Inc., Mass Spec Rev 30:1121-1142, 2011
语种英语
WOS记录号WOS:000297015700009
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142422
专题中国科学院大连化学物理研究所
作者单位1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Nanjing Normal Univ, Jiangsu Key Lab Biofunct Mat, Sch Chem & Environm Sci, Nanjing 210097, Peoples R China
推荐引用方式
GB/T 7714
Yuan, Gu,Zhang, Qiang,Zhou, Jiang,et al. MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION[J]. MASS SPECTROMETRY REVIEWS,2011,30(6):1121-1142.
APA Yuan, Gu,Zhang, Qiang,Zhou, Jiang,&Li, Huihui.(2011).MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION.MASS SPECTROMETRY REVIEWS,30(6),1121-1142.
MLA Yuan, Gu,et al."MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION".MASS SPECTROMETRY REVIEWS 30.6(2011):1121-1142.
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