DICP OpenIR
MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION
Yuan, Gu1; Zhang, Qiang1; Zhou, Jiang1; Li, Huihui1,2
KeywordMass Spectrometry G-quadruplex Dna Formation Recognition Conversion
Source PublicationMASS SPECTROMETRY REVIEWS
2011-11-01
DOI10.1002/mas.20315
Volume30Issue:6Pages:1121-1142
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Technology
WOS SubjectSpectroscopy
WOS Research AreaSpectroscopy
WOS KeywordHUMAN TELOMERIC DNA ; END-LINKED OLIGONUCLEOTIDES ; INTRAMOLECULAR G-QUADRUPLEX ; HIV-1 INTEGRASE INHIBITORS ; THROMBIN-BINDING APTAMER ; DIMERIC G-QUADRUPLEXES ; GAS-PHASE ; PROMOTER REGION ; C-MYC ; GUANINE-QUADRUPLEXES
AbstractG-quadruplexes are special secondary structures formed from G-rich sequences of DNA, and have proven to play important roles in a number of biological systems, including the regulation of gene transcription and translation. The highly distinctive nature of G-quadruplex structures and their functions suggest that G-quadruplexes can act as novel targets for drug development. As a highly sensitive analytical tool, mass spectrometry has been widely used for the analysis of G-quadruplex structures. Electrospray-ionization mass spectrometry, in particular, has found captivating applications to probe interactions between small molecules and G-quadruplex DNA. In this review, we will discuss: (1) mass spectrometry probing of the formation, binding affinity, and stoichiometry between G-quadruplexes and small molecules; (2) stabilization and collision-dissociation behavior of G-quadruplex DNA; (3) the exploration of the equilibrium transfer between a G-quadruplex and duplex DNA; and (4) the ESI-MS analysis of the conversion of intramolecular and intermolecular G-quadruplexes. Finally, we will also introduce the application of new techniques in the analysis of G-quadruplex conformation, such as ion-mobility and infrared multiphoton-dissociation mass spectrometry. We believe that, with the new technical developments, mass spectrometry will play an unparalleled role in the analysis of the G-quadruplex structures. (C) 2011 Wiley Periodicals, Inc., Mass Spec Rev 30:1121-1142, 2011
Language英语
WOS IDWOS:000297015700009
Citation statistics
Cited Times:50[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142422
Collection中国科学院大连化学物理研究所
Affiliation1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Nanjing Normal Univ, Jiangsu Key Lab Biofunct Mat, Sch Chem & Environm Sci, Nanjing 210097, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Gu,Zhang, Qiang,Zhou, Jiang,et al. MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION[J]. MASS SPECTROMETRY REVIEWS,2011,30(6):1121-1142.
APA Yuan, Gu,Zhang, Qiang,Zhou, Jiang,&Li, Huihui.(2011).MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION.MASS SPECTROMETRY REVIEWS,30(6),1121-1142.
MLA Yuan, Gu,et al."MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION".MASS SPECTROMETRY REVIEWS 30.6(2011):1121-1142.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yuan, Gu]'s Articles
[Zhang, Qiang]'s Articles
[Zhou, Jiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yuan, Gu]'s Articles
[Zhang, Qiang]'s Articles
[Zhou, Jiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yuan, Gu]'s Articles
[Zhang, Qiang]'s Articles
[Zhou, Jiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.