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题名: MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION
作者: Yuan, Gu1;  Zhang, Qiang1;  Zhou, Jiang1;  Li, Huihui1, 2
关键词: mass spectrometry ;  G-quadruplex DNA ;  formation ;  recognition ;  conversion
刊名: MASS SPECTROMETRY REVIEWS
发表日期: 2011-11-01
DOI: 10.1002/mas.20315
卷: 30, 期:6, 页:1121-1142
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Spectroscopy
研究领域[WOS]: Spectroscopy
英文摘要: G-quadruplexes are special secondary structures formed from G-rich sequences of DNA, and have proven to play important roles in a number of biological systems, including the regulation of gene transcription and translation. The highly distinctive nature of G-quadruplex structures and their functions suggest that G-quadruplexes can act as novel targets for drug development. As a highly sensitive analytical tool, mass spectrometry has been widely used for the analysis of G-quadruplex structures. Electrospray-ionization mass spectrometry, in particular, has found captivating applications to probe interactions between small molecules and G-quadruplex DNA. In this review, we will discuss: (1) mass spectrometry probing of the formation, binding affinity, and stoichiometry between G-quadruplexes and small molecules; (2) stabilization and collision-dissociation behavior of G-quadruplex DNA; (3) the exploration of the equilibrium transfer between a G-quadruplex and duplex DNA; and (4) the ESI-MS analysis of the conversion of intramolecular and intermolecular G-quadruplexes. Finally, we will also introduce the application of new techniques in the analysis of G-quadruplex conformation, such as ion-mobility and infrared multiphoton-dissociation mass spectrometry. We believe that, with the new technical developments, mass spectrometry will play an unparalleled role in the analysis of the G-quadruplex structures. (C) 2011 Wiley Periodicals, Inc., Mass Spec Rev 30:1121-1142, 2011
关键词[WOS]: HUMAN TELOMERIC DNA ;  END-LINKED OLIGONUCLEOTIDES ;  INTRAMOLECULAR G-QUADRUPLEX ;  HIV-1 INTEGRASE INHIBITORS ;  THROMBIN-BINDING APTAMER ;  DIMERIC G-QUADRUPLEXES ;  GAS-PHASE ;  PROMOTER REGION ;  C-MYC ;  GUANINE-QUADRUPLEXES
语种: 英语
WOS记录号: WOS:000297015700009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142422
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Nanjing Normal Univ, Jiangsu Key Lab Biofunct Mat, Sch Chem & Environm Sci, Nanjing 210097, Peoples R China

Recommended Citation:
Yuan, Gu,Zhang, Qiang,Zhou, Jiang,et al. MASS SPECTROMETRY OF G-QUADRUPLEX DNA: FORMATION, RECOGNITION, PROPERTY, CONVERSION, AND CONFORMATION[J]. MASS SPECTROMETRY REVIEWS,2011,30(6):1121-1142.
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