DICP OpenIR
A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress
Gao, Xinghua1; Zhang, Xu1; Tong, Huiyu2; Lin, Bingcheng1; Qin, Jianhua1
KeywordDifferentiation Mesenchymal Stem Cell Microfluidic Tensile Stress
Source PublicationELECTROPHORESIS
2011-11-01
DOI10.1002/elps.201100237
Volume32Issue:23Pages:3431-3436
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordMECHANICAL STIMULATION ; MARROW ; FORCE ; FATE
AbstractThis work presents a simple membrane-based microfluidic chip for the investigation of proliferation and differentiation of mesenchymal stem cells (MSCs) under mechanical stimuli. The cyclic tensile stress was generated by the deformation of elastic PDMS membrane sandwiched between the two layer microfluidic chip via actuated negative pressure, and the cultured MSCs on membrane were subjected to different orders of tensile stress. The results suggest that mechanical stimuli are attributed to the different phenomena of MSCs in cell proliferation and differentiation. The higher tensile stress (>3.5) promoted obvious proliferation, osteogenesis and reduced adipogenesis in MSCs, indicating the possible regulative role of tensile stress in modifying the osteogenesis/adipogenesis balance in the development of tissue organ.
Language英语
WOS IDWOS:000298300900017
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142443
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Gen Hosp PLA, Dept Neurosurg, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Gao, Xinghua,Zhang, Xu,Tong, Huiyu,et al. A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress[J]. ELECTROPHORESIS,2011,32(23):3431-3436.
APA Gao, Xinghua,Zhang, Xu,Tong, Huiyu,Lin, Bingcheng,&Qin, Jianhua.(2011).A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress.ELECTROPHORESIS,32(23),3431-3436.
MLA Gao, Xinghua,et al."A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress".ELECTROPHORESIS 32.23(2011):3431-3436.
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