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题名: Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene
作者: Lin, Sen2;  Li, Sufang1;  Chen, Zan1;  He, Xiangwei1;  Zhang, Youyi1;  Xu, Xiaojie2;  Xu, Ming1;  Yuan, Gu2
关键词: G-Quadruplex ;  3'-Flanking region ;  Cepharanthine ;  STAT3 gene ;  Gene regulation
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2011-10-01
DOI: 10.1016/j.bmcl.2011.07.121
卷: 21, 期:19, 页:5987-5991
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: G-Quadruplexes have been proved to exist in 5'-untranslated region (5'-UTR), promoter, intron and exon regions of many human genes. Here we report an intramolecular G-quadruplex formed by a G-rich sequence in the 3'-flanking region of signal transducers and activators of transcription 3 (STAT3) gene. The results showed that this G-rich sequence could affect the expression of STAT3. When the STAT3 G-quadruplex was stabilized by a novel non-planar ligand Cepharanthine (CEP), the decreased expression of STAT3 was observed in primary cultured cardiomyocytes. We also demonstrated that the down-regulation of STAT3 was most likely occurred at the transcriptional level. Our results provide a new clue for studying the G-quadruplex formation, recognition and function in the 3'-flanking region of gene. (C) 2011 Elsevier Ltd. All rights reserved.
关键词[WOS]: CIRCULAR-DICHROISM ;  MASS-SPECTROMETRY ;  TELOMERIC DNA ;  TUMOR-CELLS ;  BINDING ;  STABILIZATION ;  INHIBITION ;  MECHANISMS ;  CONVERSION ;  TETRAPLEX
语种: 英语
WOS记录号: WOS:000294714400071
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142478
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Vasc Med, Hosp 3, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Lin, Sen,Li, Sufang,Chen, Zan,et al. Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(19):5987-5991.
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