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Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene
Lin, Sen2; Li, Sufang1; Chen, Zan1; He, Xiangwei1; Zhang, Youyi1; Xu, Xiaojie2; Xu, Ming1; Yuan, Gu2
关键词G-quadruplex 3'-flanking Region Cepharanthine Stat3 Gene Gene Regulation
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2011-10-01
DOI10.1016/j.bmcl.2011.07.121
21期:19页:5987-5991
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]CIRCULAR-DICHROISM ; MASS-SPECTROMETRY ; TELOMERIC DNA ; TUMOR-CELLS ; BINDING ; STABILIZATION ; INHIBITION ; MECHANISMS ; CONVERSION ; TETRAPLEX
英文摘要G-Quadruplexes have been proved to exist in 5'-untranslated region (5'-UTR), promoter, intron and exon regions of many human genes. Here we report an intramolecular G-quadruplex formed by a G-rich sequence in the 3'-flanking region of signal transducers and activators of transcription 3 (STAT3) gene. The results showed that this G-rich sequence could affect the expression of STAT3. When the STAT3 G-quadruplex was stabilized by a novel non-planar ligand Cepharanthine (CEP), the decreased expression of STAT3 was observed in primary cultured cardiomyocytes. We also demonstrated that the down-regulation of STAT3 was most likely occurred at the transcriptional level. Our results provide a new clue for studying the G-quadruplex formation, recognition and function in the 3'-flanking region of gene. (C) 2011 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000294714400071
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142478
专题中国科学院大连化学物理研究所
作者单位1.Peking Univ, Inst Vasc Med, Hosp 3, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
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Lin, Sen,Li, Sufang,Chen, Zan,et al. Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(19):5987-5991.
APA Lin, Sen.,Li, Sufang.,Chen, Zan.,He, Xiangwei.,Zhang, Youyi.,...&Yuan, Gu.(2011).Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(19),5987-5991.
MLA Lin, Sen,et al."Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.19(2011):5987-5991.
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