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题名: Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS
作者: Zuo, Aihua1;  Wang, Li1;  Xiao, Hongbin1;  Li, Limin2;  Liu, Yuhong2;  Yi, Jinhai2
关键词: Absorbed components ;  HPLC-ESI-MS ;  Rat plasma ;  Ligusticum chuanxiong ;  Metabolism
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2011-12-15
DOI: 10.1016/j.jpba.2011.08.010
卷: 56, 期:5, 页:1046-1056
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: An HPLC-ESI-MS/MS method was established to identify the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction (RCD), a well-known traditional Chinese medicine. By comparing the extracted ion chromatograms (EICs) obtained from dosed rat plasma, blank rat plasma and RCD, a total of 25 compounds were detected in dosed rat plasma. Among them, 13 compounds were absorbed into rat plasma in prototype and identified as ferulic acid, senkyunolide J, senkyunolide I, senkyunolide D or 4,7-dihydroxy-3-butylphthalide, senkyunolide F, senkyunolide M, senkyunolide Q senkyunolide A, E-butylidenephthalide, E-ligustilide, neocnidilide, Z-ligustilide, levistolide A, according to the retention times, UV, MS, MS/MS spectra. In addition, 12 conjugated metabolites including 6 senkyunolide I-related metabolites, 4 senkyunolide J-related metabolites and 2 butylidenephthalide-related metabolites were also detected and identified by comparing their MS, MS/MS spectra with that of corresponding original components. Conjugated with glutathione, cysteine, glucuronic acid and sulphuric acid were the main metabolic reactions of phthalides. Finally the in vivo metabolic pathways of chemical constituents of Chuanxiong in rat plasma were proposed in this study. (C) 2011 Elsevier B.V. All rights reserved.
关键词[WOS]: CHROMATOGRAPHY-MASS SPECTROMETRY ;  MAJOR BIOACTIVE COMPONENT ;  LIGUSTICUM-CHUANXIONG ;  CONSTITUENTS ;  PHARMACOKINETICS ;  SENKYUNOLIDE ;  DERIVATIVES ;  MOUSE ;  AORTA
语种: 英语
WOS记录号: WOS:000295304100026
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142501
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Sichuan Acad Chinese Med Sci, Chengdu 610041, Sichuan, Peoples R China

Recommended Citation:
Zuo, Aihua,Wang, Li,Xiao, Hongbin,et al. Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,56(5):1046-1056.
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