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Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS
Zuo, Aihua1; Wang, Li1; Xiao, Hongbin1; Li, Limin2; Liu, Yuhong2; Yi, Jinhai2
关键词Absorbed Components Hplc-esi-ms Rat Plasma Ligusticum Chuanxiong Metabolism
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2011-12-15
DOI10.1016/j.jpba.2011.08.010
56期:5页:1046-1056
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CHROMATOGRAPHY-MASS SPECTROMETRY ; MAJOR BIOACTIVE COMPONENT ; LIGUSTICUM-CHUANXIONG ; CONSTITUENTS ; PHARMACOKINETICS ; SENKYUNOLIDE ; DERIVATIVES ; MOUSE ; AORTA
英文摘要An HPLC-ESI-MS/MS method was established to identify the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction (RCD), a well-known traditional Chinese medicine. By comparing the extracted ion chromatograms (EICs) obtained from dosed rat plasma, blank rat plasma and RCD, a total of 25 compounds were detected in dosed rat plasma. Among them, 13 compounds were absorbed into rat plasma in prototype and identified as ferulic acid, senkyunolide J, senkyunolide I, senkyunolide D or 4,7-dihydroxy-3-butylphthalide, senkyunolide F, senkyunolide M, senkyunolide Q senkyunolide A, E-butylidenephthalide, E-ligustilide, neocnidilide, Z-ligustilide, levistolide A, according to the retention times, UV, MS, MS/MS spectra. In addition, 12 conjugated metabolites including 6 senkyunolide I-related metabolites, 4 senkyunolide J-related metabolites and 2 butylidenephthalide-related metabolites were also detected and identified by comparing their MS, MS/MS spectra with that of corresponding original components. Conjugated with glutathione, cysteine, glucuronic acid and sulphuric acid were the main metabolic reactions of phthalides. Finally the in vivo metabolic pathways of chemical constituents of Chuanxiong in rat plasma were proposed in this study. (C) 2011 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000295304100026
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142501
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Sichuan Acad Chinese Med Sci, Chengdu 610041, Sichuan, Peoples R China
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GB/T 7714
Zuo, Aihua,Wang, Li,Xiao, Hongbin,et al. Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,56(5):1046-1056.
APA Zuo, Aihua,Wang, Li,Xiao, Hongbin,Li, Limin,Liu, Yuhong,&Yi, Jinhai.(2011).Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,56(5),1046-1056.
MLA Zuo, Aihua,et al."Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 56.5(2011):1046-1056.
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