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Preparation of Perphenylcarbamoylated beta-Cyclodextrin-silica Hybrid Monolithic Column with "One-Pot" Approach for Enantioseparation by Capillary Liquid Chromatography
Zhang, Zhenbin1,2; Wu, Minghuo1; Wu, Ren'an1; Done, Jing1; Ou, Junjie1; Zou, Hanfa1
Source PublicationANALYTICAL CHEMISTRY
2011-05-01
DOI10.1021/ac200414r
Volume83Issue:9Pages:3616-3622
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordCHIRAL STATIONARY-PHASE ; CHARGED POLYACRYLAMIDE-GELS ; ENANTIOMERIC SEPARATIONS ; BONDED SILICA ; NEUTRAL COMPOUNDS ; ELECTROCHROMATOGRAPHY ; HPLC ; CEC ; POLYMERIZATION ; DERIVATIVES
AbstractPerphenylcarbamoylated beta-cycloclextrin-silica (Ph-beta-CD-silica) hybrid monolithic columns for enantioseparation in capillary liquid chromatography (cLC) have been prepared by a "one-pot" approach via the polycondensation of alkoxysilanes and in situ copolymerization of mono (6(A)-N-allylamino-6(A)-deoxy)-Ph-beta-CD and vinyl group on the precondensed siloxanes. The morphologies of the Ph-beta-CD-silica hybrid monolithic columns were characterized by optical microscopy and scanning electron microscopy (SEM), showing the uniform monolithic matrixes tightly bonded onto the capillary wall. The content of Ph-beta-CD incorporated in monolithic matrix by the "one-pot" approach was ca. 2.9 times higher than that by postmodification method. The permeability of the Ph-beta-CD-silica chiral hybrid monolithic column was 3.63 x 10(-14) m(2), and the minimum plate height was 12 pm corresponding to 83 300 theoretical plates/meter. Enantioseparations of 13 racemates were achieved by the Ph-beta-CD-silica hybrid monolithic column. In this work, since the prepolymerization system mainly consisted of organic solvent (methanol (MeOH), N, N-dimethylformamide (DMF)), the limitation and difficulty of the use of water insoluble organic monomers in the previously reported "one-pot" method was circumvented. Therefore, various beta-CD derivatives as well as other hydrophobic monomers could thus be used to prepare organic silica hybrid monolithic columns with the "one-pot" process.
Language英语
WOS IDWOS:000289956800058
Citation statistics
Cited Times:99[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142538
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zhenbin,Wu, Minghuo,Wu, Ren'an,et al. Preparation of Perphenylcarbamoylated beta-Cyclodextrin-silica Hybrid Monolithic Column with "One-Pot" Approach for Enantioseparation by Capillary Liquid Chromatography[J]. ANALYTICAL CHEMISTRY,2011,83(9):3616-3622.
APA Zhang, Zhenbin,Wu, Minghuo,Wu, Ren'an,Done, Jing,Ou, Junjie,&Zou, Hanfa.(2011).Preparation of Perphenylcarbamoylated beta-Cyclodextrin-silica Hybrid Monolithic Column with "One-Pot" Approach for Enantioseparation by Capillary Liquid Chromatography.ANALYTICAL CHEMISTRY,83(9),3616-3622.
MLA Zhang, Zhenbin,et al."Preparation of Perphenylcarbamoylated beta-Cyclodextrin-silica Hybrid Monolithic Column with "One-Pot" Approach for Enantioseparation by Capillary Liquid Chromatography".ANALYTICAL CHEMISTRY 83.9(2011):3616-3622.
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