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题名: Preparation of Perphenylcarbamoylated beta-Cyclodextrin-silica Hybrid Monolithic Column with "One-Pot" Approach for Enantioseparation by Capillary Liquid Chromatography
作者: Zhang, Zhenbin1, 2;  Wu, Minghuo1;  Wu, Ren'an1;  Done, Jing1;  Ou, Junjie1;  Zou, Hanfa1
刊名: ANALYTICAL CHEMISTRY
发表日期: 2011-05-01
DOI: 10.1021/ac200414r
卷: 83, 期:9, 页:3616-3622
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Perphenylcarbamoylated beta-cycloclextrin-silica (Ph-beta-CD-silica) hybrid monolithic columns for enantioseparation in capillary liquid chromatography (cLC) have been prepared by a "one-pot" approach via the polycondensation of alkoxysilanes and in situ copolymerization of mono (6(A)-N-allylamino-6(A)-deoxy)-Ph-beta-CD and vinyl group on the precondensed siloxanes. The morphologies of the Ph-beta-CD-silica hybrid monolithic columns were characterized by optical microscopy and scanning electron microscopy (SEM), showing the uniform monolithic matrixes tightly bonded onto the capillary wall. The content of Ph-beta-CD incorporated in monolithic matrix by the "one-pot" approach was ca. 2.9 times higher than that by postmodification method. The permeability of the Ph-beta-CD-silica chiral hybrid monolithic column was 3.63 x 10(-14) m(2), and the minimum plate height was 12 pm corresponding to 83 300 theoretical plates/meter. Enantioseparations of 13 racemates were achieved by the Ph-beta-CD-silica hybrid monolithic column. In this work, since the prepolymerization system mainly consisted of organic solvent (methanol (MeOH), N, N-dimethylformamide (DMF)), the limitation and difficulty of the use of water insoluble organic monomers in the previously reported "one-pot" method was circumvented. Therefore, various beta-CD derivatives as well as other hydrophobic monomers could thus be used to prepare organic silica hybrid monolithic columns with the "one-pot" process.
关键词[WOS]: CHIRAL STATIONARY-PHASE ;  CHARGED POLYACRYLAMIDE-GELS ;  ENANTIOMERIC SEPARATIONS ;  BONDED SILICA ;  NEUTRAL COMPOUNDS ;  ELECTROCHROMATOGRAPHY ;  HPLC ;  CEC ;  POLYMERIZATION ;  DERIVATIVES
语种: 英语
WOS记录号: WOS:000289956800058
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142538
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Zhang, Zhenbin,Wu, Minghuo,Wu, Ren'an,et al. Preparation of Perphenylcarbamoylated beta-Cyclodextrin-silica Hybrid Monolithic Column with "One-Pot" Approach for Enantioseparation by Capillary Liquid Chromatography[J]. ANALYTICAL CHEMISTRY,2011,83(9):3616-3622.
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