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题名: The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin
作者: Hu, Wenbing1;  Luo, Qun1;  Wu, Kui1;  Li, Xianchan1;  Wang, Fuyi1;  Chen, Yi1;  Ma, Xiaoyan2;  Wang, Jianping2;  Liu, Jianan1;  Xiong, Shaoxiang1;  Sadler, Peter J.3
刊名: CHEMICAL COMMUNICATIONS
发表日期: 2011
DOI: 10.1039/c1cc11627d
卷: 47, 期:21, 页:6006-6008
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Cisplatin, cis-[Pt(Cl-2(NH3)(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.
关键词[WOS]: HUMAN SERUM-ALBUMIN ;  BINDING-SITES ;  MASS-SPECTROMETRY ;  PROTEIN-BINDING ;  PLATINUM ;  DNA ;  COMPLEXES ;  CANCER ;  CIS-DIAMMINEDICHLOROPLATINUM(II) ;  CHEMOTHERAPY
语种: 英语
WOS记录号: WOS:000290628000016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142550
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, CAS Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
2.Chinese Acad Sci, State Key Lab Mol React Dynam, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
3.Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

Recommended Citation:
Hu, Wenbing,Luo, Qun,Wu, Kui,et al. The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin[J]. CHEMICAL COMMUNICATIONS,2011,47(21):6006-6008.
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