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题名: Oligonucleotide-functionalized gold nanoparticles-enhanced QCM-D sensor for mercury(II) ions with high sensitivity and tunable dynamic range
作者: Chen, Qiang1;  Wu, Xiaojie1;  Wang, Dingzhong1;  Tang, Wei1;  Li, Na1;  Liu, Feng1
刊名: ANALYST
发表日期: 2011
DOI: 10.1039/c1an00010a
卷: 136, 期:12, 页:2572-2577
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: A quartz crystal microbalance with dissipation monitoring (QCM-D) sensor was developed for highly sensitive and specific detection of mercury(II) ions (Hg2+) with a tunable dynamic range, using oligonucleotide-functionalized gold nanoparticles (GNPs) for both frequency and dissipation amplification. The fabrication of the sensor employed a 'sandwich-type' strategy, and formation of T-Hg2+-T structures in linker DNA reduced the hybridization of the GNPs-tagged DNA on the gold electrode, which could be used as the molecular switch for Hg2+ sensing. This QCM-D mercury sensor showed a linear response of 10-200 nM, with detection limits of 4 nM and 7 nM for frequency and dissipation measurements, respectively. Moreover, the dynamic range of the sensor could be tuned by simply altering the concentration of linker DNA without designing new sensors in the cases where detection of Hg2+ at different levels is required. This sensor afforded excellent selectivity toward Hg2+ compared with other potential coexisting metal ions. The feasibility of the sensor was demonstrated by analyzing Hg2+-spiked tap- and lake-water samples with satisfactory recoveries. The proposed approach extended the application of the QCM-D system in metal ions sensing, and could be adopted for the detection of other analytes when complemented with the use of functional DNA structures.
关键词[WOS]: QUARTZ-CRYSTAL MICROBALANCE ;  PIEZOELECTRIC SENSOR ;  CIRCULAR-DICHROISM ;  BASE-PAIRS ;  METAL-IONS ;  TRACE HG2+ ;  TURN-ON ;  BIOSENSOR ;  REMEDIATION ;  BINDING
语种: 英语
WOS记录号: WOS:000291164900019
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142553
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Qiang,Wu, Xiaojie,Wang, Dingzhong,et al. Oligonucleotide-functionalized gold nanoparticles-enhanced QCM-D sensor for mercury(II) ions with high sensitivity and tunable dynamic range[J]. ANALYST,2011,136(12):2572-2577.
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