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Synthesis and Evaluation of Nanoglobular Macrocyclic Mn(II) Chelate Conjugates as Non-Gadolinium(III) MRI Contrast Agents
Tan, Mingqian1,2; Ye, Zhen3; Jeong, Eun-Kee3; Wu, Xueming1; Parker, Dennis L.3; Lu, Zheng-Rong1
刊名BIOCONJUGATE CHEMISTRY
2011-05-01
DOI10.1021/bc100573t
22期:5页:931-937
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]NEPHROGENIC SYSTEMIC FIBROSIS ; MANGANESE(II) COMPLEXES ; SILSESQUIOXANE CORE ; RELAXIVITY ; GADOLINIUM ; TOXICITY ; EXPOSURE ; CYCLEN ; LIGAND ; LIVER
英文摘要Because of the recent observation of the toxic side effects of Gd(III) based MRI contrast agents in patients with impaired renal function, there is strong interest on developing alternative contrast agents for MRI. In this study, macrocyclic Mn(II) chelates were conjugated to nanoglobular carriers, lysine dendrimers with a silsesquioxane core, to synthesize non-Gd(III) based MRI contrast agents. A generation 3 nanoglobular conjugate of Mn(II)-1,4,7-triaazacyclononane-1,4,7-triacetate-GA amide (G3-NOTA-Mn) was also synthesized and evaluated. The per ion T-1 and T-2 relaxivities of G2, G3, G4 nanoglobular Mn(II)-DOTA monoamide conjugates decreased generation of the carriers. The T-1 relaxivities of G2, G3, and G4 nanoglobular Mn(II)-DOTA conjugates were 3.3, 2.8, and 2.4 mM(-1) s(-1) per Mn(II) chelate at 3 T, respectively. The T-1 relaxivity of G3-NOTA-Mn was 3.80 mM(-1) s(-1) per Mn(II) chelate at 3 T. The nanoglobular macrocyclic Mn(II) chelate conjugates showed good in vivo stability and were readily excreted via renal filtration. The conjugates resulted in much less nonspecific liver enhancement than MnCl2 and were effective for contrast-enhanced tumor imaging in nude mice bearing MDA-MB-231 breast tumor xenografts at a dose of 0.03 mmol Mn/kg. The nanoglobular macrocyclic Mn(II) chelate conjugates are promising nongadolinium based MRI contrast agents. with increasing
语种英语
WOS记录号WOS:000290691600011
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被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142555
专题中国科学院大连化学物理研究所
作者单位1.Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
3.Univ Utah, Dept Radiol, Salt Lake City, UT 84108 USA
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Tan, Mingqian,Ye, Zhen,Jeong, Eun-Kee,et al. Synthesis and Evaluation of Nanoglobular Macrocyclic Mn(II) Chelate Conjugates as Non-Gadolinium(III) MRI Contrast Agents[J]. BIOCONJUGATE CHEMISTRY,2011,22(5):931-937.
APA Tan, Mingqian,Ye, Zhen,Jeong, Eun-Kee,Wu, Xueming,Parker, Dennis L.,&Lu, Zheng-Rong.(2011).Synthesis and Evaluation of Nanoglobular Macrocyclic Mn(II) Chelate Conjugates as Non-Gadolinium(III) MRI Contrast Agents.BIOCONJUGATE CHEMISTRY,22(5),931-937.
MLA Tan, Mingqian,et al."Synthesis and Evaluation of Nanoglobular Macrocyclic Mn(II) Chelate Conjugates as Non-Gadolinium(III) MRI Contrast Agents".BIOCONJUGATE CHEMISTRY 22.5(2011):931-937.
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