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MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status
Li, Wei1,2; Liu, Yong1; Li, Xue-Xia3; Yu, Yang1; Wu, Jing-Jing1; Wang, Qing4; Huo, Hong1; Wang, Li-Ming5; Yang, Ling1
关键词Triptolide Tripterygium Wilfordii Celastraceae Prostate Cancer P53 Mitogen Activated Protein Kinases (Mapks)
刊名PLANTA MEDICA
2011
DOI10.1055/s-0030-1250076
77期:1页:27-31
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]EPITHELIAL-CELLS ; PRIMARY CULTURES ; DRUG-RESISTANCE ; ACTIVATION ; KINASE ; PATHWAYS ; PROTEIN ; P38 ; PHOSPHORYLATION ; CHEMOTHERAPY
英文摘要Triptolide showed excellent antitumor activity against several solid tumors. However, its mechanism has not been fully understood. To further elucidate it, the effects of mitogen activated protein kinases (MAPKs) on the activity of triptolide towards prostate cancer cell lines were investigated in the present study using both LNCaP (p53 positive and androgen-dependent) and PC-3 (p53 deficient and androgen-independent) cells. Our results showed that triptolide exerted potent growth inhibitory and apoptotic effects on both cell lines, and the effects were independent of the expression of p53. Although upregulation of ERK and JNK phosphorylation was observed after the triptolide treatment, the results with inhibitors showed that these MAPKs were not involved in the mechanism of triptolide activity in human prostate cancer cell lines with different p53 status.
语种英语
WOS记录号WOS:000285406500005
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/142556
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Dalian Univ, Affiliated Zhongshan Hosp, Dept Oncol, Dalian, Peoples R China
4.Dalian Univ Technol, Dalian, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 2, Dept Gen Surg, Dalian 116027, Peoples R China
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GB/T 7714
Li, Wei,Liu, Yong,Li, Xue-Xia,et al. MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status[J]. PLANTA MEDICA,2011,77(1):27-31.
APA Li, Wei.,Liu, Yong.,Li, Xue-Xia.,Yu, Yang.,Wu, Jing-Jing.,...&Yang, Ling.(2011).MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status.PLANTA MEDICA,77(1),27-31.
MLA Li, Wei,et al."MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status".PLANTA MEDICA 77.1(2011):27-31.
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