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MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status
Li, Wei1,2; Liu, Yong1; Li, Xue-Xia3; Yu, Yang1; Wu, Jing-Jing1; Wang, Qing4; Huo, Hong1; Wang, Li-Ming5; Yang, Ling1
KeywordTriptolide Tripterygium Wilfordii Celastraceae Prostate Cancer P53 Mitogen Activated Protein Kinases (Mapks)
Source PublicationPLANTA MEDICA
2011
DOI10.1055/s-0030-1250076
Volume77Issue:1Pages:27-31
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS KeywordEPITHELIAL-CELLS ; PRIMARY CULTURES ; DRUG-RESISTANCE ; ACTIVATION ; KINASE ; PATHWAYS ; PROTEIN ; P38 ; PHOSPHORYLATION ; CHEMOTHERAPY
AbstractTriptolide showed excellent antitumor activity against several solid tumors. However, its mechanism has not been fully understood. To further elucidate it, the effects of mitogen activated protein kinases (MAPKs) on the activity of triptolide towards prostate cancer cell lines were investigated in the present study using both LNCaP (p53 positive and androgen-dependent) and PC-3 (p53 deficient and androgen-independent) cells. Our results showed that triptolide exerted potent growth inhibitory and apoptotic effects on both cell lines, and the effects were independent of the expression of p53. Although upregulation of ERK and JNK phosphorylation was observed after the triptolide treatment, the results with inhibitors showed that these MAPKs were not involved in the mechanism of triptolide activity in human prostate cancer cell lines with different p53 status.
Language英语
WOS IDWOS:000285406500005
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/142556
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Dalian Univ, Affiliated Zhongshan Hosp, Dept Oncol, Dalian, Peoples R China
4.Dalian Univ Technol, Dalian, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 2, Dept Gen Surg, Dalian 116027, Peoples R China
Recommended Citation
GB/T 7714
Li, Wei,Liu, Yong,Li, Xue-Xia,et al. MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status[J]. PLANTA MEDICA,2011,77(1):27-31.
APA Li, Wei.,Liu, Yong.,Li, Xue-Xia.,Yu, Yang.,Wu, Jing-Jing.,...&Yang, Ling.(2011).MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status.PLANTA MEDICA,77(1),27-31.
MLA Li, Wei,et al."MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status".PLANTA MEDICA 77.1(2011):27-31.
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