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题名: MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status
作者: Li, Wei1, 2;  Liu, Yong1;  Li, Xue-Xia3;  Yu, Yang1;  Wu, Jing-Jing1;  Wang, Qing4;  Huo, Hong1;  Wang, Li-Ming5;  Yang, Ling1
关键词: triptolide ;  Tripterygium wilfordii ;  Celastraceae ;  prostate cancer ;  p53 ;  mitogen activated protein kinases (MAPKs)
刊名: PLANTA MEDICA
发表日期: 2011
DOI: 10.1055/s-0030-1250076
卷: 77, 期:1, 页:27-31
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: Triptolide showed excellent antitumor activity against several solid tumors. However, its mechanism has not been fully understood. To further elucidate it, the effects of mitogen activated protein kinases (MAPKs) on the activity of triptolide towards prostate cancer cell lines were investigated in the present study using both LNCaP (p53 positive and androgen-dependent) and PC-3 (p53 deficient and androgen-independent) cells. Our results showed that triptolide exerted potent growth inhibitory and apoptotic effects on both cell lines, and the effects were independent of the expression of p53. Although upregulation of ERK and JNK phosphorylation was observed after the triptolide treatment, the results with inhibitors showed that these MAPKs were not involved in the mechanism of triptolide activity in human prostate cancer cell lines with different p53 status.
关键词[WOS]: EPITHELIAL-CELLS ;  PRIMARY CULTURES ;  DRUG-RESISTANCE ;  ACTIVATION ;  KINASE ;  PATHWAYS ;  PROTEIN ;  P38 ;  PHOSPHORYLATION ;  CHEMOTHERAPY
语种: 英语
WOS记录号: WOS:000285406500005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/142556
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Dalian Univ, Affiliated Zhongshan Hosp, Dept Oncol, Dalian, Peoples R China
4.Dalian Univ Technol, Dalian, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 2, Dept Gen Surg, Dalian 116027, Peoples R China

Recommended Citation:
Li, Wei,Liu, Yong,Li, Xue-Xia,et al. MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status[J]. PLANTA MEDICA,2011,77(1):27-31.
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